Antinuclear antibodies (ANA) in a Colombian cohort of pediatric patients with autoimmune diseases (PAID)
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POSTER PRESENTATION
Open Access
Antinuclear antibodies (ANA) in a Colombian cohort of pediatric patients with autoimmune diseases (PAID) MD Yepez Ricardo1*, MD Malagon Clara2, Consuelo Romero-Sanchez3, MD Mosquera Catalina4 From 18th Pediatric Rheumatology European Society (PReS) Congress Bruges, Belgium. 14-18 September 2011 Background ANA is an important diagnostic tool in PAID. The type of staining patterns by IFF technique and the final titer varies according of the type of PAID. Aim To evaluate the ANA type of patterns and titer on a cohort of PAID patients in a referral pediatric rheumatology center in Bogotá. Methods Retrospective descriptive study of a PAID cohort. Results 363 patients were included. 66% had JIA, 11% JSLE, 7% juvenile undifferentiated autoimmune disease(JUAD), 4% Scleroderma, 4% JDM, 1% uveitis ANA + and a group of other PAID 11%. ANA positivity varies according to the subtype of JIA from 0-68%. Positive AAN: JSLE 93%, scleroderma 85%, JDM 63%. Most JUAD had ANA + at low titers. A heterogeneous group of other PAID showed a variable titers and patterns of ANA .The most prevalent type of pattern was speckled, followed by homogenous and other pattern were uncommon. On JSLE, the prevalence and titers were higher and multiple auto antibodies were detected at the time of diagnosis. (Table 1). Conclusion ANA positivity is not specific for PAID. Its interpretation should be based on a good clinical correlation and
Table 1 Disease
N
ANA +
Speckled Homogeneous ≤1:320 >1:320
JIA
98/ 240
41%
96%
4%
91%
9%
JSLE
37/40
93%
70%
24%
35%
65%
JUAD
24/24
100% 83%
13%
63%
37%
JDM
8/13
62%
62%
38%
88%
12%
Scleroderma 11/13
85%
82%
18%
55%
45%
Other PAID
24/31
71%
71%
21%
67%
33%
Uveitis ANA +
3/3
100% 100%
0%
100%
0%
additional work up in order to classified and confirm PAID. Author details 1 Pediatric Rheumatology Fellowship program, Universidad el Bosque, Bogotá, Colombia. 2Pediatric Rheumatology Fellowship program, Universidad el Bosque, Bogotá, Colombia. 3Instituto UIBO, Universidad el Bosque, Bogotá, Colombia. 4Pediatric Rheumatology Fellowship program, Universidad el Bosque, Bogotá, Colombia. Published: 14 September 2011
doi:10.1186/1546-0096-9-S1-P230 Cite this article as: Ricardo et al.: Antinuclear antibodies (ANA) in a Colombian cohort of pediatric patients with autoimmune diseases (PAID). Pediatric Rheumatology 2011 9(Suppl 1):P230.
* Correspondence: [email protected] 1 Pediatric Rheumatology Fellowship program, Universidad el Bosque, Bogotá, Colombia Full list of author information is available at the end of the article © 2011 Ricardo et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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