Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China
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RESEARCH
Open Access
Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China Ying-Ying Zheng1,2, Xiang Xie1,2, Yi-Tong Ma1,2*, Yi-Ning Yang1,2, Zhen-Yan Fu1,2, Xiao-Mei Li1,2, Shuo Pan1,2, Dilare Adi1,2, Bang-Dang Chen2 and Fen Liu2
Abstract Background: Complement 5a receptor (C5aR) was demonstrated a receptor of complement 5a (C5a) which is involved in many inflammatory diseases. The functional responses attributed to C5a results from its interaction with its receptors C5aR, which stimulates food intake, plays a role in increasing the inflammatory response in adipose tissue as well as the cardiovascular and neural systems. However, There are unknown associations between the SNPs of C5aR1 gene and coronary artery disease (CAD). Methods: We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5aR1 gene for CAD using a case–control design, and determined the prevalence of C5aR1 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population. Results: The rs10853784 was found to be associated with CAD in dominant model (CC vs TT + CT, P = 0.004). The difference remained statistically significant after multivariate adjustment (OR = 1.430, 95% CI: 1.087 ~ 1.882, P = 0.011). There was no significant difference in genotype distributions of rs4577202 and rs7250152 between CAD patients and control subjects. The frequency of the haplotype (A-T-C) was significantly higher in the CAD patients than in the controls (P = 0.035), and the haplotype (A-C-T) was significantly lower in the CAD patients than in the control subjects in Chinese Han population (P = 0.002). Conclusion: The results of this study indicate that rs10853784 of C5aR1 gene are associated with CAD in Han population of China, and A-C-T haplotypes may be protective genetic marker and the A-T-C may be risk genetic marker for CAD in Chinese Han population. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ 2054871241495194. Keywords: C5aR1 gene, Single nucleotide polymorphism, Case–control study, Coronary artery disease
Background The role of the immune system and inflammatory pathways in the development of atherosclerotic disease is well established [1]. Recent evidences claimed that inflammation might represent the pathophysiological link between obesity and metabolic syndrome (MetS) [2]. Since adipose tissue is now considered an endocrine * Correspondence: [email protected] 1 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, P.R., China 2 Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, P.R., China
organ, affecting metabolism and vascular function. The understanding of these pathways is crucial from a pathophysiological point of coronary artery disease (CAD) risk stratification and to the identification of possible therapeutic targets. Disorders of lipoprotein metabolism such as elevated levels of triglycerid
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