Association of carcinoid tumor and low grade glioma
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CASE REPORT
WORLD JOURNAL OF SURGICAL ONCOLOGY
Open Access
Association of carcinoid tumor and low grade glioma Emeline Tabouret1,2*, Maryline Barrié2, Cecile Vicier1, Anthony Gonçalves1, Olivier Chinot2, Patrice Viens1 and Anne Madroszyk1
Abstract Background: Lung carcinoid tumor and low grade glioma are two uncommon malignancies. Patients and methods: We report the case of 24-year-old man who presented with respiratory disease. Imaging investigations showed a right lung tumor and histological analysis confirmed a typical carcinoid tumor. As part of initial staging, brain MRI revealed an asymptomatic right frontal lesion. First, a right pulmonary lobectomy was performed without adjuvant treatment. In second time, brain tumorectomy was performed. Histological examination confirmed the diagnosis of low grade glioma (LGG). The patient remained in complete remission 2.5 years after the initial diagnosis. Results: This is the first case reporting the association between LGG and lung carcinoid tumor, while no association between LGG and a systemic tumor have been published to date. Association of lung carcinoid tumor with other malignant diseases has been reported but remained uncommon. Only minimal data support a potential molecular common origin. Conclusion: This exceptional association may be fortuitous. However, their concomitant diagnoses suggest a potential association between both rare diseases. A genetic susceptibility remains possible.
Background Carcinoid bronchopulmonary tumors represent approximately 1 to 2% of all lung neoplasms. Low grade glioma (LGG) are rare, diffuse, slow-growing, primary neuroectodermal tumors that occur in the central nervous system. In this report, we present the first association between LGG and lung carcinoid tumor. We also performed a comprehensive review of the literature on the association between LGG or carcinoid tumor, and systemic malignancies. Case presentation A 24-year-old man presented in September 2009 with respiratory symptoms including cough and hemoptoic expectorations, without altered general status. Past medical history was restricted to Oto-Rhino-Laryngological viral infections without smoking, alcohol, or asbestos * Correspondence: [email protected] 1 Département d’Oncologie Médicale, Institut Paoli-Calmettes, 232 Boulevard Ste Marguerite, 13009 Marseille, France 2 Service de Neuro-Oncologie, Assistance Publique des Hôpitaux de Marseille, Hôpital de le Timone, Marseille, France
exposure. Clinical observation was not relevant with normal respiratory and neurological examinations. Thoracic radiography showed a mass in the right lung. Computed tomography (CT) confirmed a lung tumor (56 mm) in the right superior lobe associated with mediastinal lymph node involvement without visceral metastasis. First, lung fibroscopy was performed. It was complicated by massive hemoptysis. Histological analysis concluded a diagnosis of typical carcinoid tumor. Positron emission tomography was moderate positive (Standardized Uptake Value = 4) and octreoscan presented an
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