Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene
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META-ANALYSIS
Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis Qiuyan Li1 • Yuandong Qiao1 • Chuntao Wang1 • Guangfa Zhang1 Xuelong Zhang1 • Lidan Xu1
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Received: 18 June 2015 / Accepted: 5 October 2015 / Published online: 18 November 2015 Ó Springer Science+Business Media New York 2015
Abstract The objective of the study is to assess the association between rs1801278 and rs2943641 of insulin receptor substrate 1 gene (IRS1) and the susceptibility to type 2 diabetes. A literature search strategy was conducted to identify all references lists of relevant studies. The fixed or random effect model was used to calculate the pooled ORs on the basis of heterogeneity. Further analyses were performed to explore the sources of heterogeneity by sensitivity analysis, meta-regression analysis, and subgroup analysis. There was significant association between rs1801278 and type 2 diabetes risk in recessive model (AA vs. GA ? GG, p = 0.043) and codominant model (AA vs. GG, p = 0.007). Subgroup analysis showed that the association between rs1801278 and type 2 diabetes risk was significant in dominant model (GA ? AA vs. GG, p = 0.044), codominant model (GA vs. GG, p = 0.039), codominant model (AA vs. GG, p = 0.044), overdominant model (GG ? AA vs. GA, p = 0.037) in Asian and codominant model (AA vs. GG, p = 0.039) in Caucasian of rs1801278. The association between rs2943641 and type 2 diabetes risk was significant in codominant model (CT vs. CC, p = 0.023) in Caucasian. This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian. It also indicates that rs2943641 may be
Qiuyan Li and Yuandong Qiao have contributed equally to this work.
Electronic supplementary material The online version of this article (doi:10.1007/s12020-015-0770-z) contains supplementary material, which is available to authorized users. & Lidan Xu [email protected] 1
Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, People’s Republic of China
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associated with type 2 diabetes risk in Caucasian. Further larger studies should be performed to warrant confirmation. Keywords Meta-analysis IRS1 Type 2 diabetes Polymorphism Susceptibility
Introduction Diabetes is one of the most common metabolic disorders that cause considerable morbidity and mortality worldwide. The global prevalence of diabetes was estimated to be 9 % among adult in 2014, and in 2012, 1.5 million deaths were directly caused by diabetes (http://www.who.int/en/). Type 2 diabetes comprises 90 % of people with diabetes around the world, is a chronic disease associated with a ten-yearshorter life expectancy, and is characterized by impaired insulin secretion and insulin resistance (IR) to the peripheral actions of insulin [1]. Environmental and genetic factors contribute together to the development of type 2 diabetes [2]; however, the fundamental molecular mechanism causing the disease remains far
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