Atadenovirus
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. OAdV-7 (strain 287). Fig. 1 ˚ resolution as determined by cryoelectron microscopy. The particle is viewed along a fivefold axis of Virus structure at 10.6 A symmetry (pink dots). Yellow dots indicate LH3 trimers. The threefold axis passes through the center of the triangle. Length of bar (nm): 50 (Image provided by Radosav Pantelic and modified by the author)
Virion Morphology:
Icosahedral
Envelope:
No
Diameter (nm):
94
Length (nm):
–
Structural components: 52/55 k, VII, X; capsid II, III, IIIa, IV, VI, VIII, p32k, LH3 Buoyant density (g/mL): 1.3 Buoyant density method:
CsCl
Lipid composition: Additional information:
Gene LH3 encodes a 42 kDa protein which forms prominent trimeric knobs on the virion surface around the threefold axis of symmetry (> Fig. 1).
C. Tidona, G. Darai (eds.), The Springer Index of Viruses, DOI 10.1007/978-0-387-95919-1, # Springer Science+Business Media, LLC 2011
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Atadenovirus
Genome Nucleic acid:
DNA
Strandedness:
Double-stranded
Polarity:
–
Configuration:
Linear
Segment Organization: Segment no. 1 (kb):
27.7–31.3
One segment(s): G + C content (%):
33.6–50.2
mRNA transcripts:
>40
27.7–31.3 (kb) total (calculated)
Open Reading Frames: 29–31 Additional information: Transcripts partly defined for OAdV-7 only. DAdV-1 has additional transcription units at the right end
Replication Entry mechanism:
Receptor mediated endocytosis
Site of yranscription:
Nucleus
Transcriptase:
Cellular RNA polymerase II
Site of genome replication:
Nucleus
Replicase:
Virus-encoded DNA-dependent DNA polymerase
Replication intermediate:
Each strand of the dsDNA is a template for a daughter strand
Site of virion assembly:
Nucleus
Egress mechanism:
Cell lysis (OAdV-7)
Additional information:
Viral genome remains autonomous
History Year of event
Event
References
1966
Isolation of bovine adenovirus serotypes 4 and 5
Bartha A, Aldasy P (1966) Acta Vet Acad Sci Hung 16:107–108
1968
Isolation of bovine adenovirus serotype 6
Rondhuis PR (1968) Arch Ges Virusforsch 25:235–236
1970
Isolation of Bovine adenovirus serotype 7
Matumoto M et al (1970) Jap J Microbiol 14:430–431
1970
Isolation of Bovine adenovirus serotype 8
Bartha A et al (1970) Acta Vet Acad Sci Hung 20:399–400
1976
Isolation of egg drop syndrome virus from poultry
McFerran JB et al (1978) Avian Path 7:35–47
1982
Isolation of ovine adenovirus type 7 (OAdV-7) from sheep in Western Peet RL et al (1983) Aust Vet J 60:307–308 Australia
1996
Complete genome sequence of OAdV strain 287 determined
Vrati S et al (1996) Virology 220:186–199
Atadenovirus
. Electron micrograph of negatively stained ‘‘core’’ particles of OAdV. Fig. 2 Cores are exposed when the hexon/LH3 capsid layer is lost from a mutant with an N-terminal mutation in LH3 (Pantelic et al (2008) J Virol 82:7346–7356. Hexon trimers (short arrow) penton/fiber complexes (long arrow) litter the background. Scale bar 50 nm (Courtesy of Radosav Pantelic and Ben Hankamer)
Year of event
Event
References
1996
OAdV-7 developed as a gene
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