BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer
- PDF / 262,721 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 54 Downloads / 170 Views
ORIGINAL RESEARCH
BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer Shiva Behzadi 1 & Behzad Baradaran 2 & Mohammad Ali Hosseinpourfeizi 1 & Narges Dastmalchi 1 & Ali Rajabi 1 & Milad Asadi 2 & Reza Safaralizadeh 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression. Objective The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC. Methods QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent nontumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated. Results BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (P = 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters. Conclusion LncRNA BC032913 may be considered as an impressive therapeutic target for GC. Keywords Gastric cancer . Long non-coding RNA BC032913 . Clinicopathological parameters . qRT-PCR
Introduction GC has been considered as the fourth most currently occurring malignant tumor and the second leading reason for cancerrelated fatality [1]. Recent progressions in diagnosis and therapy have increased the long-term survival rate of patients with GC in primary stages; however, it must be mentioned that GC has indicated a poor prognosis at advanced stages [2]. It is considerable and urgent to realize the molecular mechanisms underlying GC tumorigenesis to propose an impressive biomarker for GC diagnosis and therapy. Non-coding RNAs are categorized into two groups of short and long non-coding * Reza Safaralizadeh [email protected] 1
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
RNAs based on their length. The cluster of short non-coding RNAs includes miRNAs, piRNAs, snoRNAs, and siRNAs. LncRNAs are a heterogeneous class of non-coding RNAs [3–8]. Based on the position in the genome, lncRNA genes can be classified into the following subgroups: sense overlapping RNAs, natural antisense transcripts, intergenic non-coding RNAs, sense intronic RNAs, and processed transcripts [9–11]. Researchers have indicated that lncRNAs can modulate the expression of genes via transcription, chromatin remodeling, and post-transcriptional modifications [12–15]. LncRNAs can act as molecular scaffolds or decoys that modulate the expression of genes throug
Data Loading...
