Bilirubin: Jekyll and Hyde Pigment of Life Pursuit of Its Structure

The book covers the totality of bilirubin (and heme, from which bilirubin is derived biogenetically), the structural relationship of bilirubin to its solution properties and metabolism, and to phototherapy for the jaundiced newborn - a common medical proc

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98

D.A. Lightner

Bilirubin: Jekyll and Hyde Pigment of Life

123

Progress in the Chemistry of Organic Natural Products Founded by L. Zechmeister Editors: A.D. Kinghorn, Columbus, OH H. Falk, Linz J. Kobayashi, Sapporo Honorary Editor: W. Herz, Tallahassee, FL Editorial Board: V.M. Dirsch, Vienna S. Gibbons, London N.H. Oberlies, Greensboro, NC Y. Ye, Shanghai

98 Progress in the Chemistry of Organic Natural Products Bilirubin: Jekyll and Hyde Pigment of Life; Pursuit of Its Structure Through Two World Wars to the New Millenium Author: David A. Lightner

Prof. A. Douglas Kinghorn, College of Pharmacy, Ohio State University, Columbus, OH, USA em. Univ.-Prof. Dr. H. Falk, Institut für Organische Chemie, Johannes-Kepler-Universität, Linz, Austria Prof. Dr. J. Kobayashi, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

ISSN 2191-7043 ISSN 2192-4309 (electronic) ISBN 978-3-7091-1636-4 ISBN 978-3-7091-1637-1 (eBook) DOI 10.1007/978-3-7091-1637-1 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2013956743 © Springer-Verlag Wien 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover picture: Crystals (left) of bilirubin-IXα (from CHCl3-CH3OH) photographed through polarized light. (Center) Crystalline bilirubin in bulk. (Right) Dilute solution of bilirubin in dimethyl sulfoxide. Image obtained