Bioprobes Biochemical Tools for Investigating Cell Function
This new edition provides the most advanced research using bioprobes on the chemical control of 1) cell cycle and differentiation, 2) epigenetics, 3) apoptosis and autophagy, and 4) immune response. The “bioprobe”, first proposed in the first edition, has
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Bioprobes
Biochemical Tools for Investigating Cell Function Second Edition
Bioprobes
Hiroyuki Osada Editor
Bioprobes Biochemical Tools for Investigating Cell Function Second Edition
Editor Hiroyuki Osada Chemical Biology Research Group RIKEN Center for Sustainable Resource Science Wako, Saitama Japan
ISBN 978-4-431-56527-7 ISBN 978-4-431-56529-1 DOI 10.1007/978-4-431-56529-1
(eBook)
Library of Congress Control Number: 2017936471 © Springer Japan KK 2000, 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK The registered company address is: Chiyoda First Bldg. East, 3-8-1 Nishi-Kanda, Chiyoda-ku, Tokyo 101-0065, Japan
Preface
The first edition of this book Bioprobes was published in 2000. The term “bioprobe” was introduced then as the name for a chemical tool, a probe, to investigate biological functions. Eventually, the concept of the research inspired by the bioprobe was similar to that of chemical biology and it became familiar to scientists. The epoch-making research results, namely, that FK506 and cyclosporin inhibit the activity of phosphatase calcineurin by forming the ternary complexes FK506- FKBP12- calcineurin or cyclosporine-cyclophilin-calcineurin, opened a new door in chemical biology. It was typical research in basic chemical biology. The new tide of chemical biology has flowed from the Institute of Chemistry and Cell Biology (ICCB) at Harvard Medical School and has initiated the building of chemical biology-related centers in other parts of the world. One of the main activities of the centers is the screening of small bioactive compounds from chemical libraries. This tide merged into chemical genomics, which deals with the systematic screening on a large scale from chemical libraries to discover lead compounds
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