Black and white vulvar lesions: reticulate genital melanosis and vitiligo
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Black and white vulvar lesions: reticulate genital melanosis and vitiligo Lula María Nieto‑Benito1 · Ricardo María Suárez‑Fernandez1 · Lucía Barchino‑Ortiz1 Received: 15 July 2020 / Accepted: 22 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Keywords Genital melanosis · Melanotic macule · Reticulate genital melanosis · Vitiligo · Vulvar melanoma
Fig. 1 a Genital melanotic macule with reticular configuration observed in right mayor labia associated with pubic hair and skin vitiligo in the right hemivulva. b Reticulate genital melanosis: melanotic macule with a reticulated configuration due to combination of depigmented and hyperpigmented areas. Note hypopigmented hairs growing from the centre of depigmented or edges of hyperpigmented macules
Genital melanotic macules are benign lesions that appear in oral or genital mucosa. Reticular Genital Melanosis (RGM) defines the “lattice-like” configuration that some genital macules are present. The depigmented component usually appears after melanosis had completely developed and it is restricted to the macule. A T-cell infiltrate located around
melanocytes has been found in histopathological examinations of RGM. In this clinical image, the association with hair and skin vitiligo suggests that the immune response of T cells against melanocytes, as demonstrated in vitiligo, could be considered the physiopathology of RGM (Fig. 1).
* Lula María Nieto‑Benito [email protected] 1
Department of Dermatology, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, 46 Doctor Esquerdo St, 28007 Madrid, Spain
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Author contributions All authors have contributed equally to the conception and design of the work, revise its content, and agree to publish the final version submitted to your journal. The present work has not been presented at any conference or meeting conference or published before. LMN-B: project development, data collection, manuscript writing, and manuscript writing and review. RMS-F: project development, data collection, manuscript writing, and manuscript writing and review. LB-O: project development, data collection, manuscript writing, and manuscript writing and review. Funding The authors have not received any financial support or funding on this project.
Compliance with ethical standards Conflict of interest The authors have indicated no significant interest with commercial supporters.
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Archives of Gynecology and Obstetrics Patient’s consent form Written consent was obtained from the patient for publication of clinical information and photographs.
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