Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis
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IDIOPATHIC PULMONARY FIBROSIS
Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis Angelo Zinellu1 · Panagiotis Paliogiannis2 · Elisabetta Sotgiu1 · Sabrina Mellino1 · Arduino A. Mangoni4 · Elisabetta Zinellu3 · Silvia Negri2,3 · Claudia Collu2,3 · Gianfranco Pintus1,5 · Antonello Serra6 · Angelo Maria Pistuddi6 · Ciriaco Carru1 · Pietro Pirina2,3 · Alessandro G. Fois2,3 Received: 24 May 2020 / Accepted: 10 August 2020 © The Author(s) 2020
Abstract Purpose Inflammation and immunity play a pivotal but yet unclear role in idiopathic pulmonary fibrosis (IPF), a chronic disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment. However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain. Methods Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included in this cross-sectional study. Results We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression, all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed. Conclusions In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation in IPF. Keywords Idiopathic pulmonary fibrosis · IPF · Inflammation · LMR · NLR · PLR
Introduction * Panagiotis Paliogiannis [email protected] 1
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
2
Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy
3
Unit of Respiratory Diseases, University Hospital Sassari (AOU), Sassari, Italy
4
Department of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia
5
Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research, University of Sharjah, P.O. Box: 27272, Sharjah, United Arab Emirates
6
Unit of Occupational Medicine, University Hospital Sassari (AOU), Sassari, Italy
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrosing interstitial lung disease of unknown aetiology, occurring mainly in adults, that is characterized by a histopathologic and/or radiologic pattern of usual interstitial pneumonia [1]. The progressive accumulation of fibrotic tissue leads to irreversible lung damage. As a consequence, the estimated survival of u
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