Bronchoalveolar lavage and serum KL-6 concentrations in chronic hypersensitivity pneumonitis: correlations with radiolog
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Bronchoalveolar lavage and serum KL‑6 concentrations in chronic hypersensitivity pneumonitis: correlations with radiological and immunological features Nicola Lanzarone1 · Francesco Gentili2 · Valerio Alonzi1 · Laura Bergantini1 · Miriana d’Alessandro1 · Paola Rottoli1 · Rosa Metella Refini1 · Maria Pieroni1 · Lucia Vietri1 · Francesco Bianchi1 · Maria Antonietta Mazzei3 · Luca Volterrani · Anna Perrone1 · Paolo Cameli1 · Elena Bargagli1 · Piersante Sestini1 Received: 24 October 2019 / Accepted: 19 January 2020 © Società Italiana di Medicina Interna (SIMI) 2020
Abstract Chronic hypersensitivity pneumonitis (cHP) is a fibrotic interstitial lung disease (ILD) resulting from inhalation of different organic substances and chemical compounds determining an inflammatory and immunological response in sensitized individuals. KL-6, a human mucin protein expressed by type 2 pneumocytes, has been proposed as a prognostic biomarker of cHP. Assessment of usefulness KL-6 in ILD has been investigated primarily in Asiatic population. The aim of this study was to evaluate clinical utility of KL-6 in serum and bronchoalveolar lavage (BAL). In this study, we retrospectively analysed clinical, radiological and immunological data of a cohort of 42 patients affected by cHP: KL-6 concentrations were collected from serum and BAL. KL-6 clinical value was assessed through the analysis of association between KL-6 concentrations and clinical, functional, immunological and radiological features. KL-6 serum concentration results increased in 28/34 patients (82%). A positive direct correlation was observed between KL-6 concentrations in BAL and serum (r = 0.62, p
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