Cancer: Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of t
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Birkhäuser Verlag Basel · Boston · Berlin
Editor Leon P. Bignold Division of Tissue Pathology Institute of Medical and Veterinary Science PO Box 14 Rundle Mall, SA 5001 Australia
Library of Congress Cataloging-in-Publication Data Cancer : cell structures, carcinogens and genomic instability / edited by Leon P. Bignold. p. ; cm. -- (EXS ; 96) Includes bibliographical references and index. ISBN-13: 978-3-7643-7156-2 (alk. paper) ISBN-10: 3-7643-7156-0 (alk. paper) 1. Carcinogenesis--Molecular aspects. 2. Cancer cells. 3. Cancer--Pathophysiology. 4. Cancer--Genetic aspects. I. Bignold, Leon P., 1947- II. Series [DNLM: 1. Neoplasms--genetics. 2. Carcinogens-adverse effects. 3. Gene Expression Regulation, Neoplastic--drug effects. 4. Genomic Instability. 5. Neoplasms-etiology. QZ 202 C21518 2005] RC268.5.C28 2005 616.99'4071--dc22 2005048329 Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the Internet at .
ISBN 10: 3-7643-7156-0 Birkhäuser Verlag, Basel – Boston – Berlin ISBN 13: 978-3-7643-7156-2 The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2006 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF ∞ Cover illustration: Bottom right: Somatic translocations and mis-targeting of HATs and HDACs (see Fig. 2, p. 27, detail). Bottom left: Proposed dose-response relationship for radiation-induced effects (see Fig. 1, p.168). Top right: Bioactivation of aromatic amines or amides (AA) towards ultimate DNA-reactive sulphate or acetoxy esters (see Fig. 3, p. 71, detail). Top left: A typical metaphase spread from a fifth generation (G5) mTERC–/– mouse fibroblast showing a fusion product (arrow) and 41 chromosomal arms, an example of aneuploidy (see Fig. 3, p. 56). Printed in Germany ISBN 10: 3-7643-7156-0 ISBN 13: 978-3-7643-7156-2 987654321
e-ISBN: 3-7643-7378-4 www. birkhauser.ch
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Contents List of Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Preface
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Leon P. Bignold, B. L. D. Coghlan and H. P. A. Jersmann Cancer
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