Cancer II
This book reviews recent breakthroughs in anti-cancer drug discovery. Building on the previous volume in the series, it outlines some of the most significant developments that have occurred in the field in the subsequent period that have led to new
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Michael J. Waring Editor
Cancer II
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Topics in Medicinal Chemistry
Editorial Board: P.R. Bernstein, Philadelphia, USA A.L. Garner, Ann Arbor, USA G.I. Georg, Minneapolis, USA T. Kobayashi, Tokyo, Japan J.A. Lowe, Stonington, USA N.A. Meanwell, Princeton, USA A.K. Saxena, Lucknow, India U. Stilz, Malov, Denmark C.T. Supuran, Sesto Fiorentino, Italy A. Zhang, Pudong, China
Aims and Scope Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the new topic-related series Topics in Medicinal Chemistry will cover all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. In references Topics in Medicinal Chemistry is abbreviated Top Med Chem and is cited as a journal.
More information about this series at http://www.springer.com/series/7355
Michael J. Waring Editor
Cancer II
With contributions by J. E. Campbell C. Cano K. W. Duncan M. R. V. Finlay N. S. Gray I. R. Hardcastle S. Harnor P. A. Harris J. M. Hatcher P. W. Manley O. Michielin Z. Pan J. Pickles K. G. Pike U. F. Ro¨hrig S. T. Staben N. J. Stiefl D. Toader R. A. Ward V. Zoete Y. Zuo
Editor Michael J. Waring Northern Institute for Cancer Research, Chemistry, Newcastle University Newcastle upon Tyne, UK
ISSN 1862-2461 ISSN 1862-247X (electronic) Topics in Medicinal Chemistry ISBN 978-3-319-75924-1 ISBN 978-3-319-75926-5 (eBook) https://doi.org/10.1007/978-3-319-75926-5 Library of Congress Control Number: 2018954061 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Nei
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