Capecitabine
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Capecitabine Headache successfully treated with diltiazem: case report A 36-year-old woman developed severe headaches while receiving capecitabine for adenocarcinoma; her headaches were successfully treated with diltiazem. The woman started receiving adjuvant oral capecitabine [Xeloda] 825 mg/m2 twice daily from Monday to Friday, and radiation therapy. On the third day of therapy, she developed intense throbbing generalised headaches (grade 3 headaches) that interfered with her daily activities. The woman’s headache persisted despite treatment with ibuprofen and paracetamol[acetaminophen]. Her headache resolved over the weekend, when capecitabine was not administered, but recurred upon readministration of the drug the following week. Capecitabine-induced vasospasms were suspected and oral sustained-release diltiazem 180 mg/day was initiated. Her headache promptly resolved. Diltiazem was continued for the duration of her chemo-radiation therapy without further exacerbation of headaches. Author comment: "It is likely that severe throbbing headaches induced by [5-fluorouracil or capecitabine] are the result of vascular spasm. . . We cannot exclude the possibility of nonvascular capecitabine-induced headache given the lack of magnetic resonance angiography or other vascular studies in our case." Raman AK, et al. Capecitabine-induced headache responding to diltiazem. 801091104 Chemotherapy (Basel) 53: 306-308, No. 4, Jul 2007 - USA
0114-9954/10/1162-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 28 Jul 2007 No. 1162
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