Capecitabine
- PDF / 184,083 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 104 Downloads / 141 Views
1
★S
Diabetes mellitus (first report) and hypertriglyceridaemia: case report A 56-year-old man developed diabetes mellitus and hypertriglyceridaemia during treatment with capecitabine for metastatic colon cancer. The man, who had a BMI of 30.6 kg/m2, was undergoing his seventh cycle of capecitabine [dosage not stated] when he presented with generalised weakness, severe thirst and polyuria. Blood tests revealed the following; random blood glucose 38.6 mmol/L, glycated haemoglobin (HbA1c) 9.7%, fasting total cholesterol 11.6 mmol/L, fasting triglyceride 41 mmol/L. Prior to antineoplastic therapy, his fasting total cholesterol and triglyceride levels had been 5.4 and 5.3 mmol/L, respectively. At that time, he had had normal fasting glucose and HbA1c levels, and a random blood glucose level of 8 mmol/L. The man was treated with fenofibrate and glucoselowering therapy, and capecitabine was discontinued. Within 1 week, his total cholesterol level normalised and his fasting triglyceride level decreased to 2.36 mmol/L. His glycaemic state slowly improved and, after 6 months’ treatment with metformin, his HbA1c level was 6.4%. Author comment: "Serum amylase levels were not raised in our case but it is possible that some occult, undetected low degree of pancreatic injury occurred with the cyclical capecitabine use. This may have lowered the threshold for diabetes in a patient with altered glucose homeostasis. This could explain the onset of diabetes in our patient." Garg R, et al. Capecitabine-induced severe hypertriglyceridaemia and diabetes: a case report and review of the literature. Diabetic Medicine 26: 1308-1309, No. 12, 801156539 Dec 2009 - England
»
Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of diabetes mellitus associated with capecitabine. The WHO ADR database contained ten reports of diabetes mellitus associated with capecitabine.
0114-9954/10/1284-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 16 Jan 2010 No. 1284
Data Loading...
