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Toxic epidermal necrolysis: 2 case reports A 28-year-old man and a 40-year-old woman developed toxic epidermal necrolysis (TEN) while receiving carbamazepine and lamotrigine, respectively [details of drug administrations not stated]. The man developed TEN secondary to receiving carbamazepine. He had blisters, erosions and mucosal involvement on his skin, mouth and genital areas. He was treated with hydrocortisone, immune globulin and analgesics. Fluid was regularly released from bullae with sterile needles, while thermal spring water and non-stick silicone dressings were applied to areas where skin had sloughed off. His skin healed with no scarring or infection. The woman developed TEN secondary to receiving lamotrigine. She received immune globulin, and bullae were regularly popped with sterile needles. Denuded skin areas were treated with thermal spring water and non-stick dressings. Her skin healed well with no scarring. Author comment: "We describe two patients with toxic epidermal necrolysis (TEN) who were successfully managed with Avene thermal spring water spray (ATSW), non-stick dressings and intravenous immunoglobulin (IVIg), without transfer to a burns unit." Daniel BS, et al. Concurrent Management of Toxic Epidermal Necrolysis with Thermal Water Spray and Non-Stick Dressings. Acta Dermatovenerologica Croatica 20: 210-212, No. 3, 2012. Available from: URL: http://adc.mef.hr/ 803084158 index.php/adc/issue/view/40 - Australia

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Reactions 9 Mar 2013 No. 1442