CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall surv
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Wien Klin Wochenschr https://doi.org/10.1007/s00508-020-01738-2
CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival Davor Galusic · Marko Lucijanic · Ana Livun · Maja Radman · Jelena Lucijanic · Irena Drmic Hofman · Rajko Kusec Received: 29 May 2020 / Accepted: 19 August 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Summary Background Cell division cycle 25c (CDC25c) is a gene coding a phosphatase controlling entry into mitosis upon activation through Polo-like kinase 1 (PLK1) and serves as a key regulator of cell division. The CDC25c was reported to be dysregulated in some malignant diseases, but its role in myelofibrosis has not yet been elucidated. Methods We have retrospectively investigated CDC25c mRNA expression in bone marrow aspirates of 43 paD. Galusic, MD Department of Hematology, University Hospital of Split, Soltanska 1, 21000 Split, Croatia M. Lucijanic, MD, PhD · Prof. R. Kusec, MD, PhD () Hematology Department, University Hospital Dubrava, Av. Gojka Suska 6, 10000 Zagreb, Croatia [email protected] A. Livun, PhD · Prof. R. Kusec, MD, PhD Clinical Institute of Laboratory Diagnosis, Division of Molecular Diagnosis and Genetics, University Hospital Dubrava, Av. Gojka Suska 6, 10000 Zagreb, Croatia
tients with myelofibrosis (28 primary [PMF] and 15 secondary myelofibrosis [SMF]) and 12 controls. Results CDC25c mRNA expression did not significantly differ between PMF, SMF and controls (median ΔCT 3.08 vs 2.86 vs 2.29 for PMF, SMF and controls, respectively; P = 0.162). Patients presenting with higher CDC25c mRNA expression were of older age (P = 0.037), had statistically significantly higher whiteblood-cells (P = 0.017), larger liver size (P = 0.022), higher absolute neutrophil (P = 0.010), monocyte (P = 0.050), basophil (P = 0.012), and eosinophil counts (P = 0.013). Patients presenting with high CDC25c mRNA expression had statistically significantly inferior overall survival compared to low CDC25c expression group (HR = 2.99; P = 0.049). Median overall survival was not reached in patients with low and was 44 months in patients with high CDC25c expression. Conclusion Our data suggest that higher CDC25c expression is associated with more proliferative phenotype of myelofibrosis and is prognostic of worse survival. Future studies investigating these interesting associations are warranted.
Prof. M. Radman, MD, PhD Department of Endocrinology, University Hospital of Split, Soltanska 1, 21000 Split, Croatia
Keywords Mitosis · Myeloproliferative neoplasm · Polo-like kinase 1 · Cell cycle control · Prognosis
Prof. M. Radman, MD, PhD · Prof. I. Drmic Hofman, PhD School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia
Introduction
J. Lucijanic, MD Health care center Zagreb-West, Prilaz baruna Filipovica 11, 10000 Zagreb, Croatia Prof. I. Drmic Hofman, PhD Department of Pathology, University Hospital of Split, Spinciceva 1, 21000 Split, Croatia Prof. R. Kusec, MD, PhD School of Medicine, University o
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