Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis
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ORIGINAL ARTICLE
Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis Biying Yang 1 & Yongshun Wu 2 & Yihao Wang 1 & Huili Yang 1 & Baoxin Du 1 & Wei Di 3 & Xiaotian Xu 4 & Xiaolei Shi 5 Received: 7 January 2020 / Accepted: 13 April 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Introduction Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease resulting in the dysfunction of upper and lower motor neurons. Biomarkers in fluid have been used to monitor the disease and its progression. Milk fat globuleEGF factor 8 (MFG-E8) is an inflammation modulator, which is involved in the pathogenesis of neurodegenerative diseases. We here took this study to evaluate the predictive value of MFG-E8 in ALS. Methods This study consisted of 19 patients with ALS and 15 healthy controls. Cerebrospinal fluid (CSF) were collected from all participants and tested for the levels of MFG-E8, neurofilament light (NFL), and heavy chain (NFH). The correlations between MFG-E8 and NFL, NFH, ALS severity, cognitive status, and forced vital capacity (FVC) were analyzed. Results We found that MFG-E8 performs well in distinguishing ALS from controls, with relatively higher level of MFG-E8 in ALS subjects, than controls. Moreover, MFG-E8 negatively correlated with the revised ALS function rating scale (ALS-FRS), but not with the levels of NFL and NFH, disease duration, progression rate, mini-mental state examination (MMSE), and FVC. Conclusions The study proved that CSF MFG-E8 helps distinguish ALS from controls. However, the protein in CSF negatively predicted disease severity. Keywords MFG-E8 . Amyotrophic lateral sclerosis . Cerebrospinal fluid . Disease severity
Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, which is characterized by the degeneration of upper and lower motor neurons [1]. It is the most common neurodegenerative disorder with an adult-onset form,
* Xiaolei Shi [email protected]; [email protected] 1
Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
2
Department of Radiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
3
Department of Neurology, Shaanxi Provincial People’s Hospital, The Affiliated Hospital of Northwestern Polytechnical University, Xi’an, China
4
Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou, China
5
Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China
presenting with progressive atrophy and weakness of the skeletal muscles [2]. Some patients eventually died from respiratory function. Also, about 50% of the patients exhibit cognitive impairment due presumably to breakdown of non-motor areas of the brain [3]. The pathogenesis of this disease remains to be elusive. Most patients present with a sporadic form with no identified genetic caus
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