Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with
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RESEARCH ARTICLE
Open Access
Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer Minoru Oshima1* , Keiichi Okano1, Hironobu Suto1, Yasuhisa Ando1, Hideki Kamada2, Tsutomu Masaki2, Shigeo Takahashi3, Toru Shibata3 and Yasuyuki Suzuki1
Abstract Background: Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in many types of cancer. In this study, the prognostic values of inflammatory nutritional scores were evaluated in the patients with resectable or borderline resectable pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemoradiotherapy (NACRT). Methods: A total of 49 patients who underwent pancreatectomy after NACRT from September 2009 to May 2016 were enrolled. The NACRT consisted of hypofractionated external-beam radiotherapy (30 Gy in 10 fractions) with concurrent S-1 (60 mg/m2) delivered 5 days/week for 2 weeks before pancreatectomy. Inflammatory nutritional scores were determined before and after NACRT in this series. Results: The median NLR increased after NACRT (from 2.067 to 3.302), with statistical difference (p
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