Changes in lipid profiles of epileptic mouse model
- PDF / 1,573,776 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 96 Downloads / 216 Views
ORIGINAL ARTICLE
Changes in lipid profiles of epileptic mouse model Alicia Johnson1 · Ryan A. Grove1 · Deepak Madhavan2 · Cory H. T. Boone1 · Camila Braga1 · Hannah Kyllo2 · Kaeli Samson3 · Kristina Simeone3 · Timothy Simeone3 · Tomas Helikar1 · Corrine K. Hanson4 · Jiri Adamec1 Received: 11 January 2020 / Accepted: 23 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Introduction Approximately 1% of the world’s population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists for MRE includes the ketogenic diet, a high-fat, low-carbohydrate diet. Despite the KD’s success in seizure attenuation, it has a few risks and its mechanisms remain poorly understood. The KD has been shown to improve metabolism and mitochondrial function in epileptic phenotypes. Potassium channels have implications in epileptic conditions as they have dual roles as metabolic sensors and control neuronal excitation. Objectives The goal of this study was to explore changes in the lipidome in hippocampal and cortical tissue from Kv1.1-KO model of epilepsy. Methods FT-ICR/MS analysis was utilized to examine nonpolar metabolome of cortical and hippocampal tissue isolated from a Kv1.1 channel knockout mouse model of epilepsy (n = 5) and wild-type mice (n = 5). Results Distinct metabolic profiles were observed, significant (p
Data Loading...