Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association wi
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(2020) 19:230
RESEARCH
Open Access
Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines Afsane Gholamrezayi1†, Maryam Mohamadinarab2†, Pegah Rahbarinejad2, Soudabeh Fallah3, Shekufe Rezghi Barez4, Leila Setayesh5, Nariman Moradi6, Reza Fadaei7, Elham Chamani8* and Tahmine Tavakoli9*
Abstract Background: Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. Methods: The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn’s disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits. Results: Metrnl concentration was considerably lower in both UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/ mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups. Conclusions: The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism. Keywords: Meteorin-like, Inflammatory bowel disease, Ulcerative colitis, Crohn’s disease, Interleukin, Tumor necrosis factor, Adiponectin
* Correspondence: [email protected]; [email protected] † Afsane Gholamrezayi and Maryam Mohamadinarab contributed equally to this work. 8 Cardiovascular Diseases Research Center, Department of Clinical Biochemistry, Birjand University of Medical Sciences, Birjand, Iran 9 Cardiovascular Diseases Research Center, Department of Internal Medicine, Gastroenterology Section, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in th
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