Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme
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ORIGINAL PAPER
Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme Michael L. Alosco1 · Jonathan D. Cherry1,2,3 · Bertrand Russell Huber1,3,6 · Yorghos Tripodis1,5 · Zachary Baucom5 · Neil W. Kowall1,2,3 · Nicole Saltiel1 · Lee E. Goldstein1,2,7,8,9,10 · Douglas I. Katz1,14 · Brigid Dwyer1,14 · Daniel H. Daneshvar1 · Joseph N. Palmisano1,15 · Brett Martin1,15 · Robert C. Cantu1,11,12,13 · Robert A. Stern1,11,16 · Victor E. Alvarez1,3,4 · Jesse Mez1 · Thor D. Stein1,2,3,4 · Ann C. McKee1,2,3,4 Received: 27 April 2020 / Revised: 20 July 2020 / Accepted: 21 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive head impacts (RHI) that has been neuropathologically diagnosed in American football players and other contact sport athletes. In 2013, McKee and colleagues proposed a staging scheme for characterizing the severity of the hyperphosphorylated tau (p-tau) pathology, the McKee CTE staging scheme. The staging scheme defined four pathological stages of CTE, stages I(mild)–IV(severe), based on the density and regional deposition of p-tau. The objective of this study was to test the utility of the McKee CTE staging scheme, and provide a detailed examination of the regional distribution of p-tau in CTE. We examined the relationship between the McKee CTE staging scheme and semi-quantitative and quantitative assessments of regional p-tau pathology, age at death, dementia, and years of American football play among 366 male brain donors neuropathologically diagnosed with CTE (mean age 61.86, SD 18.90). Spearman’s rho correlations showed that higher CTE stage was associated with higher scores on all semi-quantitative and quantitative assessments of p-tau severity and density (p’s
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