Cimicifuga
- PDF / 130,750 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 83 Downloads / 139 Views
1
S
Cirrhosis: case report A 44-year-old woman developed hepatotoxicity leading to early cirrhosis while receiving cimicifuga [Black Cohosh] for the treatment of menstrual symptoms [route and dosage not stated]. The woman presented with a 1-month history of jaundice. She also had elevated liver function tests. The woman was treated with steroids, but her symptoms gradually worsened. She reported generalised itching, fatigue and arthralgia. She reported that she had been taking cimicifuga for approximately 1 month to treat menstrual symptoms. Physical examination revealed jaundiced skin and scleral icterus. Laboratory investigations included the following: total bilirubin 20, AST 420, ALT 215, alkaline phosphatase 201, platelet count 135, INR 1.2 and albumin 2.4 [units not stated]. Abdominal ultrasound demonstrated nodular contour of liver consistent with cirrhosis, and a liver biopsy showed cholestasis, hepatocellular injury and early cirrhosis. Following discontinuation of cimicifuga, her symptoms improved and her liver function tests normalised. Author comment: "Given patient’s history of Black Cohosh use and the timing of her abnormal liver chemistries, it was clinically evident the culprit agent was Black Cohosh." Chaudrey K, et al. Expecting the unexpected: Black cohosh-induced hepatotoxicity leading to early cirrhosis. American Journal of Gastroenterology 108: S327, Oct 2013. Available from: URL: http://dx.doi.org/10.1038/ajg.2013.267 [abstract] 803096386 USA
0114-9954/13/1480-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Reactions 30 Nov 2013 No. 1480
Data Loading...
