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Toxic leukoencephalopathy: case report A 50-year-old woman developed toxic leukoencephalopathy during treatment with fluorouracil, cisplatin and docetaxel for locally advanced carcinoma of buccal mucosa [routes and dosages not stated]. The woman who had a history of locally advanced carcinoma of buccal mucosa with karnofsky performance status (KPS) 80-90, was started on neoadjuvant chemotherapy with fluorouracil [5-fluorouracil], cisplatin and docetaxel, due to advancement of the disease. During third cycle, on day 3 of fluorouracil infusion, she developed hypoactive delirium. Subsequently, her drowsiness progressed into a to comatose state, with Glasgow coma scale (GCS) of 5 (no verbal response, no eye opening, flexion to pain). The infusion of fluorouracil was therefore stopped. Brain MRI was also performed due to the persistence of symptoms. MRI showed T2 and fluid-attenuated inversion recovery (FLAIR) hyperintensity in the white matter of bilateral parietal region and corpus callosum and bilateral centrum semiovale with significant restriction of diffusion. On the basis of the findings, a diagnosis of toxic leukoencephalopathy secondary to the chemotherapy was made. The chemotherapy was discontinued. Three weeks later, a repeat MRI showed complete resolution of the findings. Meena VK, et al. Toxic Leukoencephalopathy: An unusual Presentation by 5-Fluorouracil Infusion. The gulf journal of oncology 1: 84-86, No. 33, May 2020. Available from: 803519744 URL: https://pubmed.ncbi.nlm.nih.gov/32476656/

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Reactions 5 Dec 2020 No. 1833