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Neutropenia and circulatory shock: case report In a retrospective study of a prospectively maintained database involving 22 patients treated between June 2000 and July 2017, a female patient [age not stated] was described, who developed neutropenia and circulatory shock during treatment with cisplatin and doxorubicin for serous papillary peritoneal carcinoma (SPPC). The woman, who had SPPC, started receiving hyperthermic intraperitoneal chemotherapy (at 42.5°C) with cisplatin 43 mg/L of perfusate and doxorubicin 15 mg/L of perfusate scheduled for 90 minutes (perfusate volume: 2.5 L/m2). She was hospitalised for total parietal peritonectomy and cytoreductive surgery prior to the chemotherapy. Subsequently, she developed haematological toxicity in the form of neutropenia and circulatory shock, that further complicated to respiratory distress [duration of treatments to reaction onsets and outcomes not stated]. Author comment: "Grade III-IV Hematological toxicities were seen in two patients. One patient developed severe neutropenia and circulatory shock with respiratory distress." Deraco M, et al. Clinico-pathological outcomes after total parietal peritonectomy, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in advanced serous papillary peritoneal carcinoma submitted to neoadjuvant systemic chemotherapy- largest single institute experience. European Journal of Surgical Oncology 45: 2103-2108, No. 11, Nov 2019. Available from: URL: http:// 803433985 doi.org/10.1016/j.ejso.2019.06.021 - Italy

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Reactions 16 Nov 2019 No. 1779