• PDF / 183,804 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 2 Downloads / 213 Views

DOWNLOAD

REPORT

---

1

★

Gastro-oesophageal reflux disease (first report with escitalopram): case report A 55-year-old woman with low energy, dysphoric mood and anhedonia developed gastro-oesophageal reflux disease (GERD) following treatment with citalopram and escitalopram [routes and durations of treatment to reactions onset not stated]. The woman began receiving citalopram 10mg every morning, and subsequently developed persistent nausea, occasional evening gastric reflux and headaches. She reported that changing the time of drug intake had no effect on her symptoms. The woman stopped taking citalopram after 3 months. A few weeks later, she began receiving escitalopram 10mg every morning. Due to persistent nausea and gastric reflux, the administration schedule was changed to evening dosing. She developed sleep disturbances as a result of increasing gastric reflux, and began receiving omeprazole on an as-needed basis. Her condition was successfully managed with desvenlafaxine and omeprazole. Author comment: The Naranjo Adverse Drug Reaction Probability Scale "indicated a probable relationship (score of 7, range of 0-12) between initiation of antidepressant therapy and the presentation of GERD symptoms in this patient." Brahm NC, et al. Antidepressant-mediated gastroesophageal reflux disease. Consultant Pharmacist 26: 274-277, No. 4, Apr 2011. Available from: URL: http:// 803060633 dx.doi.org/10.4140/tcp.n.2011.274 - USA

»

Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of gastrooesophageal reflux associated with escitalopram. The WHO ADR database contained 25 reports of gastro-oesophageal reflux disease associated with escitalopram.

0114-9954/10/1370-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved

Reactions 24 Sep 2011 No. 1370