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No response: case report A 43-year-old woman exhibited no response to clobetasol and unspecified antihistamines during treatment for IgG4-related disease [not all dose and dose frequencies stated]. The woman, who had history of type 2 diabetes mellitus, anterior uveitis, surgically operated acute lithiasic pancreatitis, presented to dermatological clinic in January 2018 with complaints of pruritic indurated plaques on the face and trunk associated with inflammation of the submaxillary glands. She started receiving topical clobetasol [clobetasol propionate] 0.05% cream twice daily and unspecified oral antihistamines. However, pruritus did not respond to these treatments. The woman was later treated with prednisone leading to improvement. Histological examination of the patch at the upper back was consistent with scleredema. A high-resolution body CT scan revealed thickening of salivary and lacrimal glands and multiple subcutaneous nodules in the armpits, neck and trunk suggestive of adenopathies. Blood IgG4 levels was 208 mg/dL. Lymph node biopsy was compatible with nodal inflammatory pseudotumour. The clinical findings confirmed a clinicopathological diagnosis of IgG4-related disease. Thereafter, she received treatment with unspecified oral corticosteroids with clinical improvement and no relapse was noted until April 2020. Rodenas-Herranz T, et al. Scleredema and nodal inflammatory pseudotumor: IgG4-related disease?. International Journal of Dermatology 59: e427-e429, No. 11, 2020. 803519302 Available from: URL: http://doi.org/10.1111/ijd.14995

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Reactions 5 Dec 2020 No. 1833