CMR of LV non-compaction cardiomyopathy: association of clinical presentation and prognosis with cardiac phenotype
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POSTER PRESENTATION
Open Access
CMR of LV non-compaction cardiomyopathy: association of clinical presentation and prognosis with cardiac phenotype Mushabbar A Syed1*, Steve W Leung2, Samy Claude Elayi3, Richard J Charnigo Jr.3 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Background Left ventricular non-compaction (LVNC) is a rare congenital disorder characterized by two layered myocardium; trabeculated (non-compacted) and a non-trabeculated (compacted). LVNC is increasingly being recognized due to better imaging technology as a cause for heart failure and sudden cardiac death; however, data on clinical and imaging characteristics remains limited. Objective To investigate the association of clinical presentation and outcomes in LVNC with cardiac phenotype by CMR. Methods Fourteen patients (mean age 33.1 ± 17.6 years, 9 male) were retrospectively identified from CMR database between December 2007 and May 2010. CMR imaging included SSFP cine in standard views and late gadolinium enhancement. Quantitative analysis included left and right ventricular function, volumes, mass, LV wall motion score and non-compacted to compacted myocardium (NC/C) ratios in different segments. Number of involved LV segments and regions of maximum NC/C ratio were also recorded. Patient’s medical records were reviewed for clinical history including NYHA functional class, ECG, telemetry, Holter/event monitoring and electrophysiology studies. Non-parametric U test, logistic regression analysis and parametric T-test were used to determine statistical significance as appropriate. 1
Loyola University, Stritch School of Medicine, Maywood, IL, USA Full list of author information is available at the end of the article
Results Seven patients presented with acute heart failure including one in cardiogenic shock. Three patients presented with syncope, one with documented ventricular tachycardia (VT). Mean LVEF was 36.2 ± 22.8% and mean RVEF 31.5 ± 16.7%. LVEF
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