Comparison of low-level light therapy and combination therapy of 5% minoxidil in the treatment of female pattern hair lo
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ORIGINAL ARTICLE
Comparison of low-level light therapy and combination therapy of 5% minoxidil in the treatment of female pattern hair loss Yang Liu 1 & Lin-lang Jiang 2 & Fang Liu 1 & Qian Qu 1 & Zhe-xiang Fan 1 & Zhi Guo 1
&
Yong Miao 1
&
Zhi-qi Hu 1
Received: 10 July 2020 / Accepted: 5 October 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract This study was conducted in order to compare the safety and efficacy of LLLT, 5% minoxidil, and combination therapy in the treatment of FPHL. A randomized controlled trial was developed to study the effect of LLLT on FPHL using a device called iHelmet®, which is equipped with 200 5mW laser diode source (650 nm) arrays. Ninety Ludwig’s types II–III FPHL patients were randomly divided into 3 groups: LLLT group (A), 5% minoxidil group (B), and combination group(C). Hair density, hair diameter, and scalp oil-secretion were detected to evaluate the treatment effect. Significant improvement of hair density and hair diameter was observed in all stages of FPHL after treatment. Oil-secretion of the three groups was decreased after treatment. The effectiveness of reducing oil-secretion in LLLT group and combination group was higher than minoxidil group (P < 0.05). For improving hair diameter and hair density, combination group was better than LLLT and minoxidil groups. No side effects were reported. Our study illustrated that LLLT is a safe and effective treatment for FPHL. Besides, LLLT can significantly improve its efficacy when used in combination with 5% minoxidil. Keywords Low-level laser therapy . Female pattern hair loss . Minoxidil . Oil-secretion . Hair density
Introduction Hair loss affects millions of people around the world. Up to 70% of men and 40% of women may experience some degree of alopecia in their lifetime [1]. Female pattern hair loss (FPHL) is the most common alopecia disease in women, which is characterized by progressive and diffuse hair loss on the top and front of the head. The frontal hairline may or may not be retained. The prevalence and severity of FPHL Yang Liu and Lin-lang Jiang contributed equally to this work and should be considered co-first authors. Yong Miao and Zhi-qi Hu contributed equally to this work and should be considered co-corresponding authors. * Yong Miao [email protected] * Zhi-qi Hu [email protected] 1
Department of Plastic and Aesthetic Surgery, Nan Fang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou 510515, Guangdong, People’s Republic of China
2
Affiliated Hospital of Xiangnan University, Chenzhou 423099, Hunan Province, People’s Republic of China
increase with age, which may have a serious psychological impact on women [2–5]. In recent years, a large number of scholars have conducted studies on the effectiveness of LLLT in treating hair loss. The effect of LLLT on hair regrowth was first observed by Endre Mester in 1967. During the experiment, mice were treated with laser to explore potential carcinogenesis caused by laser irradiation. Interestingly, they foun
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