Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children
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Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children Hatice Onur,1 Sami Hatipoğlu,2 Vefik Arıca,3,6 Nevin Hatipoğlu,4 and Seçil Gunher Arıca5
Abstract—The efficacy of Quantiferon-TB gold test (QFT-GIT) remains to be documented in pediatric population. Tuberculin skin test (TST) is a conventional test available for the diagnosis of latent tuberculosis infection (LTBI). We aimed to investigate the concordance between QFT-GIT and TST in children with and without tuberculosis infection. Ninety-seven patients, aged 3 months– 14 years, admitted to pediatric outpatient clinics of Dr. Sadi Konuk Training Hospital Bakırköy, Turkey between March 2008 and April 2009 were recruited. Demographic features, TST results, history of exposure to active tuberculosis (TB), chest X-ray findings, clinical history, presence of Bacillus Calmette Guerin (BCG) vaccination scar were recorded. Patients were categorized into four groups namely, active TB, LTBI, no TB and healthy. It was found that BCG scar positivity did not influence QFT-GIT results. There was a statistically significant agreement between QFT-GIT and TST results (κ=0.486; p
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