Comparison of the Correlation of Different Pulse Transit Time Parameters to Blood Pressure
Estimation of blood pressure (BP) based on pulse transit time (PTT) is of great interest since it can estimate BP continuously and cufflessly. In previous studies, different character points were available in ECG and in photoplethysmogram (PPG) for calcul
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Abstract
Estimation of blood pressure (BP) based on pulse transit time (PTT) is of great interest since it can estimate BP continuously and cufflessly. In previous studies, different character points were available in ECG and in photoplethysmogram (PPG) for calculating PTT. The present study aimed at comparing the correlation of BP to different PTT parameters calculated using different character points of ECG and PPG. PTT parameters were calculated as the time interval from R peak, Q valley, or S valley of ECG to the peak or valley of the first derivative of the PPG. Correlations of beat-to-beat BP to the different beat-to-beat PTT parameters were calculated for the selected 13 datasets with a total of 3910 heart beats data. The results showed that the PTT as the time interval from Q valley of the ECG to the peak of the first derivative of the PPG gave the best parameter which correlates with both the systolic blood pressure (SBP, r = −0.62 ± 0.14) and the diastolic blood pressure (DBP, r = −0.45 ± 0.18). Therefore, this method of determining PTT would be useful to improve the accuracy of estimating BP continuously and cufflessly.
W.-H. Lin O. W. Samuel G. Li (&) Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China e-mail: [email protected] W.-H. Lin O. W. Samuel Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, 518055, China Q. Liu Y.-T. Zhang Joint Research Center for Biomedical Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong
1
Introduction
ESTIMATION of blood pressure (BP) based on pulse transit time (PTT) is of great interest since it can estimate BP continuously and cufflessly [1–11]. PTT is defined as the transmission time of the blood pulse wave from the cardiac aortic valve to the peripheral artery, and is commonly calculated as the time interval from a character point of ECG to a character point of photoplethysmogram (PPG) captured from the peripheral. It is based on the principle that the higher the BP is, the shorter time it would take for the transmission of the blood pulse wave from the heart to the peripheral. In previous studies, different character points were available in ECG and in PPG for calculating PTT. The present study is aimed at comparing the correlation of BP to different PTT parameters calculated using different character points of ECG and PPG.
2
METHODS
2.1 Protocol Nine healthy adults (aged 28 ± 4 years) were recruited for the experiment. Five data sets of ECG, PPG, and continuous BP waves were captured continuously at a sample rate of 1000 Hz during the experiment for each subject. The first dataset was captured for 5 min when the subject was sitting on a chair quietly after arrival. Another 5 min of dataset was recorded while the subject maintained the same initial sitting position. Thereafter, three data sets were recorded for 5 min after each bout of exercise (running on a treadmill) for three times
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