COVID-19 in Children: Clinical Characteristics and Follow-Up Study

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COVID-19

COVID-19 in Children: Clinical Characteristics and Follow-Up Study Pei-sen Ruan 1 & Hui-qing Xu 1 & Jun-hua Wu 1 & Qi-fa Song 2 & Hai-yan Qiu 1 Accepted: 28 August 2020 # Springer Nature Switzerland AG 2020

Abstract Since December 2019, the coronavirus disease 2019 (COVID-19) has spread globally. But the clinical symptoms and detailed follow-up of children with COVID-19 infection are lacking. Here, we conducted a retrospective study including children with confirmed COVID-19. We recorded patients’ epidemiological, clinical features, and follow-up data after discharging in order to improve the awareness and treatment of children with COVID-19. Keywords Children . COVID-19-infected . Clinical features . Epidemiological . Follow-up

Introduction

Methods

Since December 2019, multiple patients of pneumonia infected with the emergence of severe acute respiratory syndrome coronavirus 2 disease (COVID-19) had been detected in Wuhan city, China [1]. With the spreading of the epidemic, other more patients had also founded in China and other countries [2]. At present, pediatric patients have been reported all over the world, mainly asymptomatic and mild infections. With the progress of the epidemic and the innovation of detection technology, it was not ruled out that pediatric patients were particularly severe, and the number of critically infected children had increased and died. As children were also susceptible to COVID-19 infection and they need more attention. So, analysis of the clinical characteristics, epidemiological characteristics, and follow-up results after discharge of pediatric patients with confirmed COVID-19 in this area was aimed at improving the awareness and treatment of children with COVID-19.

We retrospectively analyzed 5 children with COVID-19 admitted to Ningbo Women and Children’s Hospital after diagnosed on Feb 4, 2020, to April 6, 2020. Diagnosis and discharge standards were performed according to the content of the “Diagnosis and treatment guidelines for 2019 novel coronavirus pneumonia (Trial Version 7) (In Chinese) [3].” We observed and recorded the patient’s epidemiological characteristics, clinical manifestations, laboratory tests, radiography, treatment methods, and transfer return. From the beginning of hospitalization to 4 weeks after discharge, we performed a dynamic tracking including laboratory tests, radiographic inspection, and SARS-CoV-2 RT-PCT in nasopharyngeal and feces swabs. We tested the SARS-CoV-2 of feces swabs and nasopharyngeal swabs every 2 days throughout the process. We conducted a blood laboratory and radiographic 3 times (on the day of discharge, 2 weeks after discharge, and 4 weeks after discharge).

This article is part of the Topical Collection on Covid 19 * Hai-yan Qiu [email protected] Pei-sen Ruan [email protected] Hui-qing Xu [email protected] Jun-hua Wu [email protected]

Qi-fa Song [email protected] 1

Department of Pediatrics, Ningbo Women and Children’s Hospital, No.339 Liuting Street, Haishu District, Ningbo City 315000, Zhejiang Province, China