CRYSTAL STRUCTURE AND ANTI-LIVER CANCER ACTIVITY OF A NEW TETRANUCLEAR Zn COMPLEX WITH 2-ETHOXY-6-METHYLIMINOMETHYL-PHEN
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CRYSTAL STRUCTURE AND ANTI-LIVER CANCER ACTIVITY OF A NEW TETRANUCLEAR Zn COMPLEX WITH 2-ETHOXY-6-METHYLIMINOMETHYL-PHENOL Y. Li1, X. Wang1, J. Zhang1, C. Lu1, S. Chen1, C. Wu1*, X.-C. Zhu2, and F. Han2
A new metal coordination complex [Zn(L)(N3)]4 (1) based on the Schiff base ligand 2-ethoxy-6methyliminomethyl-phenol (HL) is successfully prepared via a slow evaporation method. The as-prepared metal complex is characterized by various physicochemical techniques, e.g. elemental analysis and X-ray single crystal diffraction. Furthermore, we use a mechanical grinding method to prepare nanosized crystalline complex 1 (nano-1). The anti-liver cancer activity of nano-1 is evaluated in vitro. Firstly, the cell viability and cell proliferation ability are assessed with CCK-8 and cell colony formation assay, respectively. In addition to this, the cell migration and invasion are also evaluated with the transwell assay after indicated treatment. DOI: 10.1134/S002247662007015X Keywords: Zn(II)-based coordination complex, Schiff base ligand, crystalline nanoparticles, anticancer activity.
INTRODUCTION While a large number of chemotherapeutic anticancer agents have been discovered and successfully used in clinical practice, cancer still remains one of the leading killers resulting in human deaths worldwide [1]. The clinical success of cisplatin and its analogues has aroused broad interest in the investigation of new metal-based anticancer drugs over the past few decades [2-4]. However, the platinum-based anticancer drugs suffer from some serious drawbacks such as intrinsic or acquired resistance in some cancer types and undesirable side effects [5]. There is, therefore, an urgent need to develop novel metal-based anticancer therapeutic agents with different mechanisms of action that can overcome the aforesaid drawbacks of platinum-based chemotherapeutics. Bioinorganic and medicinal chemists have focused on the design and synthesis of new metal-based anticancer agents with better biological activity and selectivity, lower toxicities and different mechanisms of action to overcome the unresolved clinical problems of cisplatin analogue drugs [6-8]. The design, synthesis, and structural characterization of Schiff base complexes are still being vividly pursued for their continuing development in the area of fundamental scientific study [9-11]. Schiff bases and their corresponding metal complexes have continued to enjoy extensive interest owing to their structural diversity and potential wide-ranging applications such as those involving their anticancer, anti-convulsant, antitumor, antifungal, antibacterial, anti-tubercular,
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Department of Infectious Diseases, Linyi Central Hospital, Linyi, Shandong, P. R. China; *[email protected]. Department of Surgery, Huai′an People′s Hospital, Huai′an, Jiangsu, P. R. China. Original article submitted May 29, 2019; revised February 11, 2020; accepted March 2, 2020. 2
0022-4766/20/6107-1117 © 2020 by Pleiades Publishing, Ltd.
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antioxidant, antimalarial, and anti-inflammatory activities
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