Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease
- PDF / 528,125 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 67 Downloads / 180 Views
DIABETES AND INSULIN RESISTANCE (M RUTTER, SECTION EDITOR)
Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease Marco Dauriz & James B. Meigs
Published online: 17 January 2014 # Springer Science+Business Media New York 2014
Abstract The large-scale genome-wide association studies conducted so far identified numerous allelic variants associated with type 2 diabetes (T2D), coronary heart disease (CHD) and related cardiometabolic traits. Many T2D- and some CHD-risk loci are also linked with metabolic traits that are hallmarks of insulin resistance (lipid profile, abdominal adiposity). Chromosome 9p21.3 and 2q36.3 are the most consistently replicated loci appearing to share genetic risk for both T2D and CHD. Although many glucose- or insulin-related trait variants are also linked with T2D risk, none of them is associated with CHD. Hence, while T2D and CHD are strongly clinically linked together, further ongoing analyses are needed to clarify the existence of a shared underlying genetic signature of these complex traits. The present review summarizes an updated picture of T2D-CHD genetics as of 2013, aiming to provide a platform for targeted studies dissecting the contribution of genetics to the phenotypic heterogeneity of T2D and CHD.
Keywords Type 2 diabetes . Cardiovascular disease . Genetic risk . Insulin resistance . Glucose homeostasis This article is part of the Topical Collection on Diabetes and Insulin Resistance
Abbreviations CARDIoGRAM
C4D DIAGRAMv3 MAGIC WTCC GWAS T2D CHD MI LD SNP MAF BMI WHR HOMA-B HOMA-IR
M. Dauriz (*) : J. B. Meigs (*) Massachusetts General Hospital, General Medicine Division, 50 Staniford St. 9th Floor, Boston, MA 02114-2698, USA e-mail: [email protected] e-mail: [email protected]
HUVEC
M. Dauriz : J. B. Meigs Department of Medicine, Harvard Medical School, Boston, MA, USA
Introduction
M. Dauriz Division of Endocrinology and Metabolic Diseases, Department of Medicine, University of Verona Medical School and Hospital Trust of Verona, Verona, Italy
Coronary Artery Disease Genome wide Replication and Meta-analysis Consortium Coronary Artery Disease Genetics Consortium Diabetes Genetics Replication and Metaanalysis Meta-Analyses of Glucose- and Insulinrelated traits Consortium Welcome Trust Case Control Consortium Genome Wide Association Study Type 2 Diabetes Coronary Heart Disease Myocardial Infarction Linkage Disequilibrium Single Nucleotide Polymorphism Minor Allele Frequency Body Mass Index Waist-to-Hip Ratio Homeostatic Model Assessment of BetaCell Function Homeostatic Model Assessment of Insulin Resistance HUman Vascular Endothelial Cells
The global epidemic of type 2 diabetes (T2D) and associated cardiovascular diseases is increasing tremendously despite great efforts in prevention and treatment [1]. Cardiovascular diseases, especially coronary heart disease (CHD), represent the leading cause of death worldwide [2] and alarming
368, Page 2 of 12
projections for upcoming years require new and more effective strategies [3]. Be
Data Loading...
