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QT interval prolongation and treatment failure: 3 case reports In a retrospective chart review that included 6 patients from January 2017 to December 2019, a 74-year-old man developed QT interval prolongation during treatment with daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) endocarditis, a 71-year-old man exhibited treatment failure during antibiotic treatment with vancomycin and daptomycin for MRSA bacteraemia secondary to cellulitis and osteomyelitis, and a 55-year-old man exhibited treatment failure during antibiotic treatment with vancomycin for MRSA pneumonia [routes and dosages not stated]. A 74-year-old man (case 4), who had a history of end-stage renal disease, ischemic heart diseases and uncontrolled diabetes mellitus, presented to the emergency department complaining of chills and rigors. He was hospitalised. After admission, Several blood cultures grew MRSA and a diagnosis of infective endocarditis was made based on the echocardiography findings that showed large vegetation in the mitral valve. He was initially started on vancomycin monotherapy for a week. Although repeated blood cultures were all negative, daptomycin was added to vancomycin on day 7. He underwent mitral valve excision, radical debridement and mitral valve tissue repair in the 4th week of his admission. A few days after surgery, he had QT interval prolongation that was attributed to daptomycin [time to reaction onset and outcome not stated] and a decision was made to stop vancomycin and daptomycin and start ceftobiprole as monotherapy. He received vancomycin and daptomycin for a total of 21 days and ceftobiprole for a total of 76 days. His course following the surgery was complicated with hospital-acquired infections, including hospital acquired pneumonia. Subsequent echocardiogram, including transesophageal echocardiography, was negative for endocarditis and no positive microbiological culture was noted for MRSA. He died 7 months later [cause of death not stated]. A 71-year-old man (case 5), who had a history of diabetes, hypertension, chronic obstructive pulmonary disease, post right above-knee amputation and vascular dementia, presented to the hospital with fever and shortness of breath for 3 days. He was hospitalised. His blood culture grew MRSA that was secondary to cellulitis and osteomyelitis. A left foot MRI scan confirmed osteomyelitis that involved the forefoot and distal end of tibia and fibula with multiple pockets of fluid collection. Empirically, upon admission, vancomycin and meropenem were started. However, because of the persistence of positive blood culture with MRSA on day 7, vancomycin was replaced with daptomycin. On day 12 of admission, his blood culture remained positive after five days of being on daptomycin. Therefore, ceftobiprole was started with vancomycin. Blood culture sterilised after two days of ceftobiprole and vancomycin therapy. To rule out the possibility of endocarditis, transesophageal echocardiography was conducted and was found to be negative. There was a good clinical re