Decreased Long-Term Respiratory Infection Risk After Bariatric Surgery: a Comprehensive National Cohort Study
- PDF / 585,553 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 65 Downloads / 164 Views
ORIGINAL CONTRIBUTIONS
Decreased Long-Term Respiratory Infection Risk After Bariatric Surgery: a Comprehensive National Cohort Study Jian-Han Chen 1,2,3,4 & Yu-Feng Wei 3,5 & Chung-Yen Chen 1,2,3,4 & Yu-Chieh Su 4,6 & Robert Shan Fon Tsai 7 & Wei-Leng Chin 1,8 & Ho-Shen Lee 3,5 Received: 31 March 2020 / Revised: 16 September 2020 / Accepted: 22 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose This study aims to determine whether bariatric surgery (BS) decreases the risk of respiratory tract infections (RTIs) in obese patients. Materials and Methods This retrospective, population-based, matched cohort study utilized data from the Taiwan National Health Insurance Research Database. All patients 18 to 55 years of age with obesity diagnosed between 2005 and 2010 were enrolled. Patients were separated into two groups based on whether they underwent BS. Two groups were selected using 1:1 propensity score matching according to age, sex, and comorbidities. The general population was also enrolled for comparison. The primary endpoint was the incidence of RTIs, including pneumonia, influenza, and bronchitis. All patients were followed up until the end of 2013, the primary endpoint, or death. Results Compared to the non-surgery group, the BS group was at significantly lower risk for RTIs (aHR 0.432, 95% CI 0.340– 0.549, p < 0.001) with shorter length of hospital stay (LOH) and lower cost. Regardless of the RTI-related mortality, pneumonia, influenza, and bronchitis rates, BS did have significant protective effects on the non-surgery group. Compared to the general population, the BS group was at higher risk for RTIs (aHR 3.601, 95% CI 2.742–4.728, p < 0.001) with similar LOH and lower cost. Conclusion Patients with obesity who underwent BS were at significantly lower risk for RTIs than obese patients who did not undergo BS but were at higher risk for RTIs than the general population. BS may result in a long-term reduction of the RTI risk. Keywords Bariatric surgery . Respiratory tract infection . RTIs . Pneumonia . Influenza . Bronchitis . Lung function
Introduction Obesity is a risk factor for infection [1, 2], including respiratory tract infections (RTIs) such as pneumonia [3] and influenza [4, 5]. Furthermore, patients with obesity are at higher risk for mortality due to RTIs [4], severe infections [5], and
hospitalization [6]. According to previous data, the relationship between the risks of overall infection and RTIs (including influenza-related pneumonia) and body mass index (BMI) is U-shaped [7, 8]. Theoretically, losing weight may have protective effects on RTIs. However, few reports have indicated that weight loss decreases the risk of RTIs.
Jian-Han Chen is first author. * Jian-Han Chen [email protected] 1
2
3
4
School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan
5
Bariatric and Metabolic International Surgery Center, Department of General Surgery, E-Da Hospital, No. 1, Yida Rd., Yanchao Dist., Kaohsiung City 824, Taiwan, Rep
Data Loading...
