Demographic characteristics, thromboembolism risk, and treatment patterns for patients with cold agglutinin disease in J
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ORIGINAL ARTICLE
Demographic characteristics, thromboembolism risk, and treatment patterns for patients with cold agglutinin disease in Japan Toyomi Kamesaki1 · Jun‑ichi Nishimura2 · Hideho Wada3 · Eric Yu4 · Elisa Tsao5 · Jaime Morales5 · Yuzuru Kanakura2,6 Received: 3 March 2020 / Revised: 30 April 2020 / Accepted: 29 May 2020 © Japanese Society of Hematology 2020
Abstract Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan. Patients with CAD (at least three claims with a CAD diagnosis; Japanese Disease Code 2830009) and non-CAD controls were retrospectively identified (2008–2017) from a large hospital-based administrative claims dataset in Japan. Cohorts were compared using conditional logistic regression. We identified 344 patients with CAD (53.2% female; mean age: 66.8 years) and 3440 matched controls. Patients with CAD had higher TE rates than controls (34.9% vs. 17.9%; P
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