Dentifrices or gels containing MMP inhibitors prevent dentine loss: in situ studies
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ORIGINAL ARTICLE
Dentifrices or gels containing MMP inhibitors prevent dentine loss: in situ studies Melissa Thiemi Kato 1 & Angelica Reis Hannas 2 & Cristiane de Almeida Baldini Cardoso 3 & Luiza de Paula Silva Cassiano 4 & Paula Andery Naves 3 & Ana Carolina Magalhães 2 & Leo Tjäderhane 5,6 & Marília Afonso Rabelo Buzalaf 2 Received: 31 January 2020 / Accepted: 14 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objectives Evaluate the effect of dentifrices or gels containing MMP inhibitors on dentine loss in situ. Materials and methods Acrylic palatal appliances containing bovine dentine blocks were divided into two rows, corresponding to the groups erosion (ERO) and erosion associated with abrasion (ERO+ABR). For ERO, the appliances were immersed in a cola drink for 5 min, 4 times/day, while for ERO+ABR, the blocks were brushed for 15 sec with a dentifrice slurry after the second and third erosive challenges. Ten volunteers took part in study 1 (S1), where the dentifrices evaluated contained 1100 ppm fluoride as NaF, 0.61% green tea extract, or 0.012% chlorhexidine digluconate. Thirteen volunteers participated in study 2 (S2), in which the treatment was performed only once (1 min) with gels containing 400 μM EGCG (EGCG400), 0.012% chlorhexidine, 1 mM FeSO4, 1.23% F (NaF), placebo, or received no treatment. Dentine loss was analyzed by profilometry (μm). Results Regarding S1, ERO+ABR induced significantly higher dentine loss compared with ERO and all dentifrices tested led to significantly lower dentine loss when compared with placebo. For S2, regardless of the conditions or times of evaluation, gels containing EGCG, CHX, or FeSO4 led to significantly less wear compared with the other groups. Conclusion Both dentifrices and gels containing MMP inhibitors significantly reduced dentine loss. Clinical relevance Dentifrices and gels containing MMP inhibitors are able to increase the protection against dentine wear, although gels have a better effect when compared with fluoride gel, lasting up to 10 days after a single application. Keywords Erosion . Dentine . Matrix metalloproteinases . Inhibitors . Toothpastes . Gels
Introduction Erosive tooth wear (ETW) is the cumulative surface loss of mineralized tooth substance with dental erosion as the primary
* Marília Afonso Rabelo Buzalaf [email protected] 1
Department of Dentistry, University of Centro Oeste Paulista FACOPH, 72 Luiz Gimenez Mocegose, Piratininga, SP, Brazil
2
Department of Oral Biology, Bauru School of Dentistry, University of São Paulo, 9-75 Al. Octávio Pinheiro Brisolla, Bauru, SP, Brazil
3
Department of Dentistry, Cruzeiro do Sul University, 868 Galvão Bueno, São Paulo, SP, Brazil
4
Department of Dentistry, Aparício Carvalho University Center, 241 Ararás street, Eldorado, Porto Velho, RO, Brazil
5
Institute of Dentistry, University of Oulu, Oulu, Finland
6
Medical Research Center Oulu, Oulu University Hospital and University of Oulu, PO Box 5281, FI – 90014 Oulu, Finland
etiological factor [1]. The inc
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