• PDF / 169,790 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 24 Downloads / 146 Views

DOWNLOAD

REPORT

---

1 S

Pneumocystis jirovecii pneumonia: case report A 45-year-old man developed pneumocystis jirovecii pneumonia following treatment with dupilumab [Dupixant] and dexamethasone [routes, dosages and durations of treatments to reaction onset not stated]. The man, who had a history of long standing severe atopic dermatitis, presented with acute hypoxemic respiratory failure and cough. Previously, he had treatment failure with methotrexate, secukinumab, apremilast, and unspecified corticosteroids for atopic dermatitis. At the current presentation, he had been receiving treatment with dupilumab for atopic dermatitis, and prior to the presentation, he had completed a low dose dexamethasone [decadron] taper therapy for his acoustic neuroma. On examination, a chest CT scan revealed multifocal ground glass infiltrates bilaterally with a thin walled cavitary lesion in the left upper lung. Navigational bronchoscopy with peri-lesional bronchoalveolar lavage testing was positive for Pneumocystis jirovecii infection. Thus, he was diagnosed with Pneumocystis jirovecii pneumonia. The man was treated with cotrimoxazole [Bactrim]. However; he developed an allergic reaction to cotrimoxazole thus his treatment was switched to atovaquone for 21 days. Follow up radiographic examinations showed resolution of opacities and near complete resolution of the cavitary lesion. Berger PA, et al. Cavitary pneumocystis jirovicii on dupixent and corticosteroid therapy. American Journal of Respiratory and Critical Care Medicine 199: No Pagination (plus 803446829 poster) abstr. A6883, No. 9, May 2019. Available from: URL: https://doi.org/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A6883 [abstract]

0114-9954/20/1787-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 18 Jan 2020 No. 1787