Dietary patterns and telomere length in community-dwelling Chinese older men and women: a cross-sectional analysis
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ORIGINAL CONTRIBUTION
Dietary patterns and telomere length in community‑dwelling Chinese older men and women: a cross‑sectional analysis Ruth Chan1,2,6 · Jason Leung3 · Nelson Tang4 · Jean Woo1,2,5 Received: 21 August 2019 / Accepted: 17 December 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Environmental and lifestyle factors that affect oxidative stress and inflammation may influence telomere length (TL). There are limited data to relate dietary patterns with TL. This study examined the association of various dietary patterns with TL in Chinese older adults. Methods We conducted a cross-sectional analysis and performed multivariate linear regression analyses using available data from 1981 (965 men, 1016 women) community-dwelling Chinese adults aged 65 years and over in Hong Kong. The interviewer administered questionnaires that covered dietary intake estimation and dietary pattern generation from the food frequency questionnaire, demographic and lifestyle factors, and self-reported medical history. TL was measured by quantitative real-time polymerase chain reaction. Results None of the dietary pattern scores including the Diet Quality Index-International (DQI-I) score, the Dietary Approaches to Stop Hypertension (DASH) score, the Mediterranean-DASH Intervention for Neurodegenerative Delay Diet (MIND) score, the Mediterranean Diet Score (MDS), the Okinawan diet score, as well as the “vegetables-fruits” pattern score, the “snacks-drinks-milk” pattern score, and the “meat-fish” pattern score were associated with TL in the age- and sex-adjusted model and the multivariate adjusted model. Conclusion Our findings suggest a minimal role of dietary patterns in telomere length in community-dwelling Chinese older adults. Keywords Telomeres · Dietary patterns · Diet · Chinese
Introduction
* Ruth Chan [email protected] 1
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
2
Centre for Nutritional Studies, The Chinese University of Hong Kong, Hong Kong SAR, China
3
Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Hong Kong SAR, China
4
Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
5
Jockey Club Institute of Ageing, The Chinese University of Hong Kong, Hong Kong SAR, China
6
Department of Medicine and Therapeutics, 9/F Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
Telomeres are repeating DNA sequences that are located at the ends of chromosomes to stabilize and prevent the chromosomes from deterioration [1]. Telomeres are naturally shortened in each cell division due to the fact that DNA polymerase does not completely replicate telomeres, which is known as the ‘end replication problem’ [2]. Telomere length (TL) is an indicator of cell turnover rate and regarded as a reliable biomarker of the biological aging process and age-related diseases. The reduction of TL is associa
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