Does Electronic Monitoring Influence Adherence to Medication? Randomized Controlled Trial of Measurement Reactivity
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ORIGINAL ARTICLE
Does Electronic Monitoring Influence Adherence to Medication? Randomized Controlled Trial of Measurement Reactivity Stephen Sutton, Ph.D. & Ann-Louise Kinmonth, M.D. & Wendy Hardeman, Ph.D. & Dyfrig Hughes, Ph.D. & Sue Boase, M.St & A. Toby Prevost, Ph.D. & Ian Kellar, D.Phil. & Jonathan Graffy, M.D & Simon Griffin, D.M & Andrew Farmer, D.M
# The Author(s) 2014. This article is published with open access at Springerlink.com
Abstract Background Electronic monitoring is recommended for accurate measurement of medication adherence but a possible limitation is that it may influence adherence. Purpose To test the reactive effect of electronic monitoring in a randomized controlled trial. Methods A total of 226 adults with type 2 diabetes and HbA1c ≥58 mmol/mol were randomized to receiving their main oral glucose lowering medication in electronic containers or standard packaging. The primary outcomes were self-reported adherence measured with the MARS (Medication Adherence Report Scale; range 5–25) and HbA1c at 8 weeks. Results Non-significantly higher adherence and lower HbA1c were observed in the electronic container group (differences in
means, adjusting for baseline value: MARS, 0.4 [95 % CI −0.1 to 0.8, p = 0.11]; HbA1c (mmol/mol), −1.02 [−2.73 to 0.71, p=0.25]). Conclusions Electronic containers may lead to a small increase in adherence but this potential limitation is outweighed by their advantages. Our findings support electronic monitoring as the method of choice in research on medication adherence. (Trial registration Current Controlled Trials ISRCT N30522359)
S. Sutton : W. Hardeman : I. Kellar Behavioural Science Group, Primary Care Unit, Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
Background
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