Dynamic characteristics of MR diffusion-weighted imaging in a rabbit liver VX-2 tumor model
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ORIGINAL ARTICLE
Dynamic characteristics of MR diffusion-weighted imaging in a rabbit liver VX-2 tumor model You-Hong Yuan • En-Hua Xiao • Zhong He • Ke Jin • Cong Ma • Jun Xiang • Jian-Hua Xiao Wei-Jian Chen
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Received: 16 February 2012 / Accepted: 23 October 2012 / Published online: 13 December 2012 Ó Japan Radiological Society 2012
Abstract Purpose To investigate prospectively dynamic characteristics of the apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) in a rabbit VX-2 tumor model. Materials and methods Forty New Zealand rabbits were included in the study, and 47 rabbit VX-2 tumor models were developed by direct and intrahepatic implantation after opening the abdominal cavities. DWI was carried out periodically and respectively on days 7, 14 and 21 after implantation. The VX-2 tumor samples were studied by pathology. The distinction of VX-2 tumors on DWI was assessed by their ADC values by analysis of variance (ANOVA) using SPSS12.0 software. Results The ADC values (mean ± SD) 9 10-3 mm2/s of 47 VX-2 tumors in the peripheral and central areas were 2.18 ± 0.29, 1.96 ± 0.33, 1.80 ± 0.35, 2.20 ± 0.29, 2.05 ± 0.30 and 1.96 ± 0.48, respectively, on days 7, 14 and 21 after implantation. ADC values of 47 VX-2 tumors in the area of the tumor periphery, center and normal parenchyma were higher when the b-value was 100 s/mm2 than those when the b-value was 300 s/mm2 (F = 17.964, p \ 0.001; F = 13.986, p \ 0.001; F = 128.681, p \ 0.001). ADC Y.-H. Yuan E.-H. Xiao (&) Z. He C. Ma J. Xiang Department of Radiology, The Second Xiang-Ya Hospital, Central South University, Changsha 410012, Hunan, China e-mail: [email protected]; [email protected] K. Jin J. Xiang W.-J. Chen Department of Pathology, Hunan Province Children’s Hospital, Changsha 410005, Hunan, China J. Xiang J.-H. Xiao Department of Epidemiology, Center for Disease Control of Hunan Province, Changsha 410005, Hunan, China
values in the area of normal liver parenchyma were higher than those in the area of the VX-2 tumor periphery and center when the b-value was 100 or 300 s/mm2. ADCs of viable tumor cells in VX-2 tumors were lower on DWI than those in the area of normal liver parenchyma around the tumor, and ADCs of dead tumor cells in VX-2 tumors were unequal, including high, equal and low values, but they were higher than in the area of normal liver parenchyma around tumors after dead tumor cells had been liquefied or had become cystic. Conclusion ADC is correlated with the tumor histology and degree of malignancy, and DWI has potential value for dynamically monitoring tumors and evaluating the degree of malignancy and therapeutic effect. Keywords Liver VX-2 tumor Diffusion-weighted imaging Apparent diffusion coefficient (ADC) Rabbit
Introduction A variety of imaging modalities, including ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine and angiography, is currently used in diagnosing and evaluating hepatocellular carcinoma (HCC) [1–5]. Further technologic
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