Earlier maternal menarche is associated with shorter newborn telomere length
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ORIGINAL ARTICLE
Earlier maternal menarche is associated with shorter newborn telomere length Lulin Wang 1,2 & Lulu Song 1,2 & Bingqing Liu 1,2 & Lina Zhang 1,2 & Mingyang Wu 1,2 & Wei Xia 2 & Yuanyuan Li 2 & Chao Xiong 3 & Zhongqiang Cao 3 & Shunqing Xu 2 & Bin Zhang 3 & Yaohua Tian 1,2 & Youjie Wang 1,2 Received: 9 December 2019 / Revised: 20 February 2020 / Accepted: 25 February 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The aim of our study was to investigate the relationship between maternal age at menarche and newborn telomere length which has been linked to lifespan and many age-related diseases. There were 734 mother-newborn pairs recruited from Wuhan Children’s Hospital Wuhan, Hubei Province, China. Age at menarche was self-reported and categorized into three groups (≤ 12 years, 13 years, and ≥ 14 years). Telomere length in cord blood was measured using quantitative real-time polymerase chain reaction and expressed as the ratio of telomere copy number to singlecopy gene number (T/S). The mean age at menarche of 734 mothers was 13.1 (± 1.1) years and the adjusted geometric means in the T/S of newborn telomeres in the three groups were 0.693, 0.721, and 0.748 respectively. Earlier age at menarche (≤ 12 years), compared with later age at menarche ≥ 14 years, was significantly associated with 7.32% (95% CI − 13.70%, − 0.23%) shorter telomere length in offspring after adjusting for potential confounders.
Communicated by Patrick Van Reempts * Youjie Wang [email protected]
Zhongqiang Cao [email protected]
Lulin Wang [email protected]
Shunqing Xu [email protected]
Lulu Song [email protected]
Bin Zhang [email protected]
Bingqing Liu [email protected]
Yaohua Tian [email protected]
Lina Zhang [email protected] Mingyang Wu [email protected]
1
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, HangKong Road 13, Wuhan 430030, Hubei, China
2
Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
3
Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Wei Xia [email protected] Yuanyuan Li [email protected] Chao Xiong [email protected]
Eur J Pediatr
Conclusion: Mothers with earlier age at menarche were more likely to give birth newborn with shorter telomere length. Our study provides evidences for the effect of earlier menarche on fetal telomere programming in offspring. What is Known: • Newborn telomere length is considered an indicator of lifespan and health outcomes in later life. • The adverse effects of earlier menarche age to their offspring have been found, but its relationship with newborn telomere length has not been
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