Effect of cyanoacrylate tissue adhesive in postoperative palatal pain management: a systematic review
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ORIGINAL ARTICLE
Effect of cyanoacrylate tissue adhesive in postoperative palatal pain management: a systematic review Mario Escobar 1 & Patrícia Pauletto 2 & Cesar Augusto Magalhães Benfatti 1 Carlos Flores-Mir 4 & Bruno Alexandre Pacheco Castro Henriques 5
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Ariadne Cristiane Cabral Cruz 1,3
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Received: 2 September 2020 / Accepted: 4 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objective To critically appraise available literature concerning the effect of cyanoacrylate tissue adhesive (CTA) in postoperative palatal pain management. Materials and methods Electronic databases (Cochrane, PubMed, LILACS, Scopus, and Web of Science) were searched, complemented with grey literature databases up to June 2020. Studies reporting the effect of cyanoacrylate tissue adhesive compared to any other methods in postoperative palatal pain management were considered eligible. The risk of bias among and across included studies was assessed. Results Finally, four studies were considered eligible. Regarding free gingival graft (FGG), cyanoacrylate tissue adhesive with hemostatic sponge promoted less postoperative pain (PP) and analgesic consumption (AC). Also, cyanoacrylate tissue adhesive with platelet-rich fibrin produced less PP and more wound healing at the palatal area than cyanoacrylate tissue adhesive and wet gauze. Additionally, cyanoacrylate tissue adhesive promoted less PP and AC than wet gauze and suture. Concerning connective tissue graft (CTG), cyanoacrylate tissue adhesive, and suture produced similar PP, AC, and willingness for retreatment. Conclusions Based on the low certainty level, cyanoacrylate tissue adhesive appears to promote less PP and AC than wet gauze and suture regarding FGG. Additionally, cyanoacrylate tissue adhesive appears to increase the effect of hemostatic sponge, contributing to the reduction of PP and AC. Regarding CTG, cyanoacrylate tissue adhesive appears to promote similar PP, AC, and willingness for retreatment than the suture. Therefore, cyanoacrylate tissue adhesive has shown promising usefulness for PP management in FGG, but not a clear benefit for CTG. Clinical relevance The adoption of different agents for the protection of the palatal donor site following gingival harvesting procedures may provide better comfort to the patient.
Supplementary Information The online version contains supplementary material available at https://doi.org/10.1007/s00784-02003683-w. * Ariadne Cristiane Cabral Cruz [email protected] Mario Escobar [email protected] Patrícia Pauletto [email protected]
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Department of Dentistry, Center for Education and Research on Dental Implants, Federal University of Santa Catarina, Florianópolis, Brazil
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Department of Dentistry, Brazilian Centre for Evidence-Based Research, Federal University of Santa Catarina, Florianópolis, Brazil
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Laboratory of Applied Virology, Federal University of Santa Catarina, Florianópolis, Brazil
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Faculty of Medicine and Dentistry, Department of Dentistry, University of Albert
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