Effect of nicorandil administration on cardiac burden and cardio-ankle vascular index after coronary intervention
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ORIGINAL ARTICLE
Effect of nicorandil administration on cardiac burden and cardio‑ankle vascular index after coronary intervention Shuji Sato1 · Mao Takahashi1 · Hiroshi Mikamo1 · Masayo Kawazoe1 · Takuo Iizuka1 · Kazuhiro Shimizu1 · Mahito Noro1 · Kohji Shirai2 Received: 13 March 2020 / Accepted: 17 June 2020 © The Author(s) 2020
Abstract Myocardial injury is a problem associated with percutaneous coronary intervention (PCI). This study aimed to clarify the role of nicorandil administration in preventing myocardial injury. This study included patients with stable angina who underwent PCI from November 2013 to June 2016. Of 58 consecutive patients, the first 20 patients received only saline infusion after PCI (control group); the other 38 patients received a continuous intravenous infusion of nicorandil and saline after PCI (nicorandil group). Troponin I and brain natriuretic peptide (BNP) levels were measured. Vascular parameters, such as blood pressure (BP), cardiac output, cardio-ankle vascular index (CAVI), and estimated systemic vascular resistance (eSVR), were measured. Troponin I of both groups increased 12 h after PCI. Changes in BNP levels between immediately after PCI and 12 h after PCI were significantly higher in the control than in the nicorandil group (10.8 ± 44.2 vs. − 2.6 ± 14.6 pg/ml, p = 0.04). In the nicorandil group, BP, eSVR, and CAVI decreased significantly at 12 h after PCI compared with those immediately after PCI (p
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