Effect of resolution recovery using graph plots on regional cerebral blood flow in healthy volunteers
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ORIGINAL ARTICLE
Effect of resolution recovery using graph plots on regional cerebral blood flow in healthy volunteers Nobuhiro Yada1,2 • Hideo Onishi1 • Masahiro Miyai3 • Kentarou Ozasa2 • Takashi Katsube4 • Keiichi Onoda5 • Masuo Haramoto2 • Yasushi Yamamoto2 Shuhei Yamaguchi5 • Hajime Kitagaki4
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Received: 2 March 2017 / Accepted: 25 June 2017 Ó The Japanese Society of Nuclear Medicine 2017
Abstract Purpose We evaluated the effect of resolution recovery (RR) using graph plots on regional cerebral blood flow (rCBF) in brain perfusion single-photon emission computed tomography (SPECT) images derived from healthy volunteers and patients diagnosed with probable Alzheimer’s disease. Method We acquired brain perfusion SPECT images with scatter correction (SC), computed tomography-based attenuation correction (CTAC), and RR from a three-dimensional brain phantom and from healthy volunteers. We then compared contrast-to-noise ratio, count density ratios, increase maps, and rCBF using statistical parametric mapping 8. Results Regional brain counts were significantly increased from 20–24% with SC, CTAC, and RR compared with SC and CTAC. Mean CBF in healthy volunteers was & Nobuhiro Yada [email protected] Hideo Onishi [email protected] 1
Biological Systems Sciences Program, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, 1-1 Gakuen-Cho, Mihara, Hiroshima 723-0053, Japan
2
Department of Radiology, Shimane University Hospital, 89-1 Enya-Cho, Izumo, Shimane 693-8501, Japan
3
Department of Radiology, Kawasaki Medical School General Medical Center, 2-6-1, Nakayamashita, Kita-Ku, Okayama 700-8505, Japan
4
Department of Radiology, Shimane University Faculty of Medicine, 89-1 Enya-Cho, Izumo, Shimane 693-8501, Japan
5
Department of Neurology, Shimane University Faculty of Medicine, 89-1 Enya-Cho, Izumo, Shimane 693-8501, Japan
42.5 ± 5.4 mL/100 g/min. Average rCBF determined using SC, CTAC and RR increased 7.5, 2.0, and 3.7% at the thalamus, posterior cingulate, and whole brain, respectively, compared with SC and CTAC. Conclusion Resolution recovery caused variations in normal rCBF because counts increased in cerebral regions. Keywords Brain perfusion Single-photon emission computed tomography Statistical parametric mapping (SPM) Computed tomography-based attenuation correction Neurology
Introduction Quantitative single-photon emission computed tomography (SPECT) quantitatively can determine the distribution of blood flow in specific cerebral regions. The pathophysiology of neurological diseases has been investigated based on regional cerebral blood flow (rCBF) determined using brain perfusion SPECT with N-isopropyl-p-[123I] iodoamphetamine (123I-IMP) [1–4]. Regional CBF has also been evaluated using microsphere models and by autoradiography with arterial blood sampling [5–7]. In contrast, rCBF can be derived using graph plots without arterial blood sampling, from mean CBF obtained by autoradiography. Graph plots have become clinically useful for measu
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