Effectiveness of theta and gamma electroacupuncture for post-stroke patients on working memory and electrophysiology: st
- PDF / 1,169,148 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 72 Downloads / 196 Views
STUDY PROTOCOL
Open Access
Effectiveness of theta and gamma electroacupuncture for post-stroke patients on working memory and electrophysiology: study protocol for a double-center, randomized, patient- and assessor-blinded, sham-controlled, parallel, clinical trial Jing-Jing Xu1,2†, Meng Ren2†, Jing-Jun Zhao2†, Jia-Jia Wu1, Si-Cong Zhang1, Yan-Biao Zhong2, Shu-Tian Xu2, Zhong-Yao Cao3, Zhi-Qing Zhou2, Yuan-Li Li2* and Chun-Lei Shan1,2*
Abstract Background: Practitioners of complementary and alternative medicine have suggested that electroacupuncture (EA) could improve post-stroke cognitive impairment, based on the clinical evidence. This study protocol is aimed at showing the effectiveness of theta and gamma EA for post-stroke patients on working memory (WM) and electrophysiology. Methods: After assessing their eligibility, 66 patients with stroke will be enrolled from two Chinese medicine hospitals and randomly divided into theta frequency EA group, gamma frequency EA group, and sham-EA group according to the ratio of 1:1:1. All patients will receive 20 sessions of EA procedures for 4 weeks. Patients in three groups will receive EA at two same acupoints in the head: Baihui (GV20) and Shenting (GV24). The frequency of the three groups of EA is set as follows: 6 Hz (theta-EA group), 40 Hz (gamma-EA group), and no current through the electrodes (sham EA). Patients and assessors will be blinded throughout the entire study. The primary outcome is the performance accuracy of 1-back task which is a frequently used measure of WM in cognitive neuroscience research contexts. Secondary outcome measures will include the response time of 1-back task, the Rivermead Behavioral Memory Test, Trail Making Test, Loewenstein Occupational Therapy Cognitive Assessment Scale, modified Barthel Index, and electroencephalogram (EEG) signals during 1-back tasks. A blinding index will be assessed. Data will be statistically analyzed by one-way ANOVA, at 5% of significance level. (Continued on next page)
* Correspondence: [email protected]; [email protected] † Jing-Jing Xu, Meng Ren and Jing-Jun Zhao contributed equally to this work. 2 Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New District, Shanghai 200000, China 1 Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Hongkou District, Shanghai 200000, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the m
Data Loading...
