Effects of ultrasound-guided erector spinae plane block on postoperative analgesia and plasma cytokine levels after unip
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ORIGINAL ARTICLE
Effects of ultrasound‑guided erector spinae plane block on postoperative analgesia and plasma cytokine levels after uniportal VATS: a prospective randomized controlled trial Lin Liu1 · Xin‑xin Ni2 · Ling‑wei Zhang1 · Kai Zhao1 · Hong Xie1 · Jiang Zhu1 Received: 26 April 2020 / Accepted: 21 August 2020 © Japanese Society of Anesthesiologists 2020
Abstract Purpose Although uniportal video-assisted thoracoscopic surgery (VATS) has been widely used, the associated postoperative pain is still severe. Currently, a variety of regional anesthesia methods have been used to relieve postoperative pain. In our study, we wanted to evaluate the effectiveness of ultrasound-guided erector spinae plane block (ESPB) as a postoperative analgesia after uniportal VATS. Methods Eighty patients scheduled to undergo uniportal VATS were randomly divided into Group ESP and Group C. In Group ESP, the patients underwent ultrasound-guided ESPB under general anesthesia before surgery, while Group C was set as blank control group without ESPB. The primary outcome was the sufentanil dose within 24 h after surgery. The secondary outcomes mainly included postoperative pain scores at 2, 4, 8, and 24 h evaluated using a numeric rating scale (NRS), intraoperative opioid dosage, levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in the plasma, side effect profile, and length of postoperative hospital stay. Results Postoperative sufentanil consumption (32.5 ± 6.3 μg vs. 42.8 ± 7.6 μg, P
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