Eight Weeks of Exercise Training on 6MWT, Heart Function, and CHF Biomarker in Patients with Chronic Heart Failure
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IMAGING
Eight Weeks of Exercise Training on 6MWT, Heart Function, and CHF Biomarker in Patients with Chronic Heart Failure Zahra Mahmoodi 1
&
Ramin Shabani 1 & Mahboubeh Gholipour 2
Accepted: 13 August 2020 / Published online: 22 August 2020 # Springer Nature Switzerland AG 2020
Abstract The aim of this study was to evaluate the effect of concurrent aerobic-resistance training (CART) on aerobic power, heart function, and biomarker in patients with chronic heart failure (CHF). A total of 76 HF with reduced ejection fraction (HFrEF) (EF < 40%) participated in the two groups, intervention group (IG, N = 38) and control group(CG, N = 38) that IG performed an 8-week CART program (3 times a week for 45–60 min) and walking (another 4 days a week for 30 min). 6MWT, heart rate variability, echocardiography parameters, NT-proBNP, and Galectin-3(Gal-3) were evaluated before and after the program. The comparison of CG and IG showed that 6MWT (277.89 ± 51.31 vs. 200.00 ± 32.33) and EF (32.89 ± 5.34vs. 32.1 ± 4.53) had increased, and DIVS (10.14 ± 0.88 vs. 10.47 ± 0.76), LVEDD (52.71 ± 6.16vs. 53.71 ± 5.12), LVESD (46.71 ± 5.68vs. 47.05 ± 6.04), heart rate (80.26 ± 7.97vs. 94.71 ± 14.52), NT-proBNP, and Gal-3 levels had decreased after 8 weeks, respectively (p < 0/ 05). The results showed that the CART program could improve aerobic power, heart rate, and echocardiographic parameters in CHF. Keywords Chronic heart failure . Exercise training . Ejection fraction . N-terminal pro-BNP . Galectin-3
Abbreviations ASE BSA CHF EF DIVS HRV LV LVEDD LVESD
American Society of Echocardiography Body surface area Congestive heart failure Ejection fraction Diastolic interventricular septal thickness Heart rate variability Left ventricle Left ventricle end-diastolic dimension Left ventricle end-systolic dimension
VO2 max NT-proBNP Gal-3 NYHA 6MWT SVR
Maximal oxygen uptake N-terminal pro b-type natriuretic peptide Galectin-3 New York Heart Association 6-min walking test Systemic vascular resistance
Introduction This article is part of the Topical Collection on Imaging * Zahra Mahmoodi [email protected] Ramin Shabani [email protected] Mahboubeh Gholipour [email protected] 1
Faculty of Humanities, Department of Physical Education and Sport Sciences, Rasht Branch, Islamic Azad University, Tehran, IR, Iran
2
Dr Heshmat Hospital, Guilan University of Medical Sciences, Rasht, IR, Iran
Chronic heart failure (CHF) is a complex clinical syndrome characterized by a disorder of ventricular function and neuroendocrine hormone secretion as well as the non-normal distribution of peripheral circulation [1, 2]. HF can be categorized in two groups: first, HF with reduced ejection fraction (HFrEF) (i.e., systolic HF) which is defined as a left ventricular ejection fraction (LVEF) of less than 40%, and second, HF with preserved ejection fraction (HFpEF) (i.e., diastolic dysfunction) which is defined as an LVEF greater than 50%. The New York Heart Association (NYHA) classifies HF patients in one of four categories based on symptoms and functi
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