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Acute kidney injury and hypotension: case report A male neonate [exact age at the time of reaction onset not stated] developed hypotension during treatment with enalapril for hypertension. Additionally, he developed acute kidney injury during treatment with gentamycin and enalapril [routes and duration of treatments to reactions onsets not stated; not all dosages stated]. The male neonate, who had prematured birth at 30th gestation weeks and very low birth weight, was admitted and had umbilical catheter placed. He had developed hypertension for which he had received propranolol and unspecified thiazide. His mother had a history of respiratory distress, and preeclampsia for which she had received methyldopa [alpha methyldopa] during her pregnancy. He was treated with gentamycin for neonatal sepsis on postnatal day 1. Then, he received enalapril 0.04 mg/kg/dose because the propranolol and unspecified thiazide did not control his BP. He then developed anuria for more than 12-hours. The male neonate underwent peritoneal dialysis for 4 days. Then, he developed oliguria and hypotension. On postnatal day 12, his kidney function tests were impaired. Based on the Kidney Diseases Improving Global Outcomes criteria stage III acute kidney injury was considered. After 4 days, anuria recovered. On postnatal day 32, the male neonate was again treated with enalapril 0.04 mg/kg. Subsequently, he developed acute kidney injury and hypotension. He responded to unspecified inotropes with electrolyte replacement and fluids. Thereafter, he did not require dialysis. The acute kidney injury and hypotension were considered to be secondary to the enalapril use. The gentamicin exposure also contributed to the development of acute kidney injury. Ozdemir-Simsek O, et al. Anuria in neonatal intensive care: Answers. Pediatric Nephrology 35: 2261-2265, No. 12, Dec 2020. Available from: URL: http://doi.org/10.1007/ s00467-020-04581-9 803518985

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Reactions 5 Dec 2020 No. 1833